Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078117355> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2078117355 endingPage "775" @default.
- W2078117355 startingPage "769" @default.
- W2078117355 abstract "The degradation behaviour of secnidazole was investigated under different stress degradation (hydrolytic, oxidative, photolytic and thermal) conditions recommended by International Conference on Harmonisation (ICH) using HPLC and LC–MS. A stability-indicating HPLC method was developed that could separate drug from degradation products formed under various conditions. Secnidazole was found to degrade significantly in alkaline conditions, oxidative stress, and also in the presence of light. Mild degradation of the drug occurred in acidic and neutral conditions. The drug was stable to dry heat. Resolution of drug and the degradation products formed under different stress studies were successfully achieved on a C-18 column utilizing water–methanol in the ratio of 85:15 and at the detection wavelength of 310 nm. The method was validated with respect to linearity, precision (including intermediate precision), accuracy, selectivity and specificity." @default.
- W2078117355 created "2016-06-24" @default.
- W2078117355 creator A5029968961 @default.
- W2078117355 creator A5085708287 @default.
- W2078117355 date "2004-11-01" @default.
- W2078117355 modified "2023-09-27" @default.
- W2078117355 title "ICH guidance in practice: establishment of inherent stability of secnidazole and development of a validated stability-indicating high-performance liquid chromatographic assay method" @default.
- W2078117355 cites W1968181988 @default.
- W2078117355 cites W1972455619 @default.
- W2078117355 cites W1975714885 @default.
- W2078117355 cites W1979320773 @default.
- W2078117355 cites W1988082425 @default.
- W2078117355 cites W2003824596 @default.
- W2078117355 cites W2024085372 @default.
- W2078117355 cites W2030795000 @default.
- W2078117355 cites W2056105745 @default.
- W2078117355 cites W2104870774 @default.
- W2078117355 doi "https://doi.org/10.1016/j.jpba.2004.08.008" @default.
- W2078117355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15533669" @default.
- W2078117355 hasPublicationYear "2004" @default.
- W2078117355 type Work @default.
- W2078117355 sameAs 2078117355 @default.
- W2078117355 citedByCount "18" @default.
- W2078117355 countsByYear W20781173552012 @default.
- W2078117355 countsByYear W20781173552013 @default.
- W2078117355 countsByYear W20781173552014 @default.
- W2078117355 countsByYear W20781173552015 @default.
- W2078117355 countsByYear W20781173552016 @default.
- W2078117355 countsByYear W20781173552018 @default.
- W2078117355 countsByYear W20781173552023 @default.
- W2078117355 crossrefType "journal-article" @default.
- W2078117355 hasAuthorship W2078117355A5029968961 @default.
- W2078117355 hasAuthorship W2078117355A5085708287 @default.
- W2078117355 hasConcept C118792377 @default.
- W2078117355 hasConcept C138268822 @default.
- W2078117355 hasConcept C154945302 @default.
- W2078117355 hasConcept C161790260 @default.
- W2078117355 hasConcept C178790620 @default.
- W2078117355 hasConcept C179998833 @default.
- W2078117355 hasConcept C185592680 @default.
- W2078117355 hasConcept C2777682752 @default.
- W2078117355 hasConcept C2779607525 @default.
- W2078117355 hasConcept C2779679103 @default.
- W2078117355 hasConcept C41008148 @default.
- W2078117355 hasConcept C43617362 @default.
- W2078117355 hasConcept C45188465 @default.
- W2078117355 hasConcept C76155785 @default.
- W2078117355 hasConcept C94412978 @default.
- W2078117355 hasConceptScore W2078117355C118792377 @default.
- W2078117355 hasConceptScore W2078117355C138268822 @default.
- W2078117355 hasConceptScore W2078117355C154945302 @default.
- W2078117355 hasConceptScore W2078117355C161790260 @default.
- W2078117355 hasConceptScore W2078117355C178790620 @default.
- W2078117355 hasConceptScore W2078117355C179998833 @default.
- W2078117355 hasConceptScore W2078117355C185592680 @default.
- W2078117355 hasConceptScore W2078117355C2777682752 @default.
- W2078117355 hasConceptScore W2078117355C2779607525 @default.
- W2078117355 hasConceptScore W2078117355C2779679103 @default.
- W2078117355 hasConceptScore W2078117355C41008148 @default.
- W2078117355 hasConceptScore W2078117355C43617362 @default.
- W2078117355 hasConceptScore W2078117355C45188465 @default.
- W2078117355 hasConceptScore W2078117355C76155785 @default.
- W2078117355 hasConceptScore W2078117355C94412978 @default.
- W2078117355 hasIssue "4" @default.
- W2078117355 hasLocation W20781173551 @default.
- W2078117355 hasLocation W20781173552 @default.
- W2078117355 hasOpenAccess W2078117355 @default.
- W2078117355 hasPrimaryLocation W20781173551 @default.
- W2078117355 hasRelatedWork W1967517180 @default.
- W2078117355 hasRelatedWork W2029680248 @default.
- W2078117355 hasRelatedWork W2046780476 @default.
- W2078117355 hasRelatedWork W2048793552 @default.
- W2078117355 hasRelatedWork W2065647693 @default.
- W2078117355 hasRelatedWork W2087046738 @default.
- W2078117355 hasRelatedWork W2089660391 @default.
- W2078117355 hasRelatedWork W2091343852 @default.
- W2078117355 hasRelatedWork W2166263961 @default.
- W2078117355 hasRelatedWork W2599388867 @default.
- W2078117355 hasVolume "36" @default.
- W2078117355 isParatext "false" @default.
- W2078117355 isRetracted "false" @default.
- W2078117355 magId "2078117355" @default.
- W2078117355 workType "article" @default.