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- W2078117655 endingPage "e25027" @default.
- W2078117655 startingPage "e25027" @default.
- W2078117655 abstract "The known virulence factor of Rift Valley fever virus (RVFV), the NSs protein, counteracts the antiviral effects of the type I interferon response. In this study we evaluated the expression of several genes in the liver and spleen involved in innate and adaptive immunity of mice immunized with a RVFV recombinant nucleocapsid protein (recNP) combined with Alhydrogel adjuvant and control animals after challenge with wild type RVFV. Mice immunized with recNP elicited an earlier IFNβ response after challenge compared to non-immunized controls. In the acute phase of liver infection in non-immunized mice there was a massive upregulation of type I and II interferon, accompanied by high viral titers, and the up- and downregulation of several genes involved in the activation of B- and T-cells, indicating that both humoral and cellular immunity is modulated during RVFV infection. Various genes involved in pro-inflammatory responses and with pro-apoptotic effects were strongly upregulated and anti-apoptotic genes were downregulated in liver of non-immunized mice. Expression of many genes involved in B- and T-cell immunity were downregulated in spleen of non-immunized mice but normal in immunized mice. A strong bias towards apoptosis and inflammation in non-immunized mice at an acute stage of liver infection associated with suppression of several genes involved in activation of humoral and cellular immunity in spleen, suggests that RVFV evades the host immune response in more ways than only by inhibition of type I interferon, and that immunopathology of the liver plays a crucial role in RVF disease progression." @default.
- W2078117655 created "2016-06-24" @default.
- W2078117655 creator A5018692865 @default.
- W2078117655 creator A5079518850 @default.
- W2078117655 creator A5081763388 @default.
- W2078117655 date "2011-09-16" @default.
- W2078117655 modified "2023-10-01" @default.
- W2078117655 title "Anti-Nucleocapsid Protein Immune Responses Counteract Pathogenic Effects of Rift Valley Fever Virus Infection in Mice" @default.
- W2078117655 cites W1519137759 @default.
- W2078117655 cites W1553440365 @default.
- W2078117655 cites W1566992315 @default.
- W2078117655 cites W1571420957 @default.
- W2078117655 cites W1637071869 @default.
- W2078117655 cites W1666139110 @default.
- W2078117655 cites W1759167934 @default.
- W2078117655 cites W1814938721 @default.
- W2078117655 cites W1886435492 @default.
- W2078117655 cites W1933079726 @default.
- W2078117655 cites W1952540413 @default.
- W2078117655 cites W1966385881 @default.
- W2078117655 cites W1966907765 @default.
- W2078117655 cites W1979307276 @default.
- W2078117655 cites W1983180570 @default.
- W2078117655 cites W1985788419 @default.
- W2078117655 cites W1989069389 @default.
- W2078117655 cites W1989440320 @default.
- W2078117655 cites W1990145253 @default.
- W2078117655 cites W1990215671 @default.
- W2078117655 cites W1992617696 @default.
- W2078117655 cites W1997369934 @default.
- W2078117655 cites W1998124123 @default.
- W2078117655 cites W1999653222 @default.
- W2078117655 cites W2001709426 @default.
- W2078117655 cites W2004124297 @default.
- W2078117655 cites W2004361019 @default.
- W2078117655 cites W2004541209 @default.
- W2078117655 cites W2008202502 @default.
- W2078117655 cites W2011883606 @default.
- W2078117655 cites W2014408171 @default.
- W2078117655 cites W2018245598 @default.
- W2078117655 cites W2019344929 @default.
- W2078117655 cites W2020213576 @default.
- W2078117655 cites W2020439954 @default.
- W2078117655 cites W2023465795 @default.
- W2078117655 cites W2024307572 @default.
- W2078117655 cites W2025173334 @default.
- W2078117655 cites W2027972306 @default.
- W2078117655 cites W2029881869 @default.
- W2078117655 cites W2032549397 @default.
- W2078117655 cites W2033495711 @default.
- W2078117655 cites W2035620364 @default.
- W2078117655 cites W2038282883 @default.
- W2078117655 cites W2043224403 @default.
- W2078117655 cites W2046034592 @default.
- W2078117655 cites W2047999732 @default.
- W2078117655 cites W2052550247 @default.
- W2078117655 cites W2054727704 @default.
- W2078117655 cites W2056450967 @default.
- W2078117655 cites W2057055394 @default.
- W2078117655 cites W2061693820 @default.
- W2078117655 cites W2071069822 @default.
- W2078117655 cites W2079601384 @default.
- W2078117655 cites W2083764534 @default.
- W2078117655 cites W2084659096 @default.
- W2078117655 cites W2085704521 @default.
- W2078117655 cites W2089474349 @default.
- W2078117655 cites W2092488874 @default.
- W2078117655 cites W2094857959 @default.
- W2078117655 cites W2095441933 @default.
- W2078117655 cites W2096457994 @default.
- W2078117655 cites W2098052012 @default.
- W2078117655 cites W2099249565 @default.
- W2078117655 cites W2100812720 @default.
- W2078117655 cites W2101456098 @default.
- W2078117655 cites W2102740981 @default.
- W2078117655 cites W2104556733 @default.
- W2078117655 cites W2105841943 @default.
- W2078117655 cites W2107124596 @default.
- W2078117655 cites W2107277218 @default.
- W2078117655 cites W2107683163 @default.
- W2078117655 cites W2111092769 @default.
- W2078117655 cites W2111544074 @default.
- W2078117655 cites W2111550951 @default.
- W2078117655 cites W2116168075 @default.
- W2078117655 cites W2116517185 @default.
- W2078117655 cites W2122181430 @default.
- W2078117655 cites W2122771828 @default.
- W2078117655 cites W2123009862 @default.
- W2078117655 cites W2127081791 @default.
- W2078117655 cites W2131071041 @default.
- W2078117655 cites W2133197586 @default.
- W2078117655 cites W2143954489 @default.
- W2078117655 cites W2147166036 @default.
- W2078117655 cites W2149891361 @default.
- W2078117655 cites W2150989762 @default.
- W2078117655 cites W2151482319 @default.
- W2078117655 cites W2152651960 @default.
- W2078117655 cites W2156841329 @default.