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- W2078119834 abstract "Islets isolated from ob/ob mice which had been fed a vitamin D-deficient diet released significantly less insulin in response to glucose than did vitamin D-replete islets but showed normal net 45Ca2+ uptake. To determine whether vitamin D3 has a direct effect on the pancreatic B cell, islets from ob/ob mice on a normal diet were exposed to vitamin D, in vitro for 1 week or only 3 h, and then glucose-stimulated 45Ca2+ uptake and insulin release were measured. Exposure to 1 nM or 1 μM vitamin D3 for 1 week stimulated 45Ca2+ uptake in the presence of 3 mti, but not 20 mM glucose, and did not affect insulin release. Exposure to vitamin D3 for 3 h did not significantly increase net 45Ca2+ uptake although there was a tendency to such an effect (P= 0.10). In conclusion, vitamin D-deficiency in vivo suppressed subsequent glucose-stimulated insulin release in vitro and this effect may be due to a direct effect of the sterol (or one of its metabolites) on calcium handling by the B cell." @default.
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- W2078119834 date "1985-01-01" @default.
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- W2078119834 title "Vitamin D<sub>3</sub>stimulates calcium-45 uptake by isolated mouse islets in vitro" @default.
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- W2078119834 doi "https://doi.org/10.1111/j.1748-1716.1985.tb07561.x" @default.
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