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• W2078121331 abstract "Objectives To systematically review and, when feasible, pool, published data regarding the prevalence of childhood neurodevelopmental delay in fetuses with increased first-trimester nuchal translucency (NT), normal karyotype and absence of structural defects or identifiable syndromes. Methods MEDLINE and SCOPUS searches using combinations of the terms ‘nuchal translucency’ AND ‘outcome*’ were complemented by perusal of the references of the retrieved articles and an additional automated search using the ‘search for related articles’ PubMed function. Only children with a normal karyotype and no structural defects or syndromic abnormalities were included in the analysis. Between-studies heterogeneity was assessed using the I2 statistic. Results The total prevalence of developmental delay in all 17 studies was 28/2458 (1.14%; 95% CI, 0.79–1.64; I2 = 57.6%). Eight studies (n = 1567) used NT > 99th centile as the cut-off; 15 children (0.96%; 95% CI, 0.58–1.58%) were reported as having developmental delay (I2 = 72.2%). Four studies (n = 669) used the 95th centile as the cut-off for increased NT; seven children (1.05%; 95% CI, 0.51–4.88%) were reported as having developmental delay (I2 = 29.2%). Five studies used 3.0 mm as the cut-off for increased NT; the pooled rate of developmental delay was six of 222 children (2.70%; 95% CI, 1.24–5.77%; I2 = 0.0%). Conclusion The rate of neurodevelopmental delay in children with increased fetal NT, a normal karyotype, normal anatomy and no identifiable genetic syndromes does not appear to be higher than that reported for the general population. More large-scale, prospective case–control studies would be needed to enhance the robustness of the results. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd." @default.
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• W2078121331 date "2011-12-23" @default.
• W2078121331 modified "2023-10-16" @default.
• W2078121331 title "Neurodevelopmental outcome of fetuses with increased nuchal translucency and apparently normal prenatal and/or postnatal assessment: a systematic review" @default.
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• W2078121331 doi "https://doi.org/10.1002/uog.10143" @default.
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