FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078125985> ?p ?o ?g. }

• W2078125985 endingPage "1153" @default.
• W2078125985 startingPage "1151" @default.
• W2078125985 abstract "2′-Fluoro-5-methyl-1-β-D-arabinosyluracil (FMAU) labeled with carbon-14 was used to image herpes simplex virus type 1-infected regions of rat brain by quantitative autoradiography. FMAU is a potent antiviral pyrimidine nucleoside which is selectively phosphorylated by virus-coded thymidine kinase. When the labeled FMAU was administered 6 hours before the rats were killed, the selective uptake and concentration of the drug and its metabolites by infected cells (defined by immunoperoxidase staining of viral antigens) allowed quantitative definition and mapping of HSV-1-infected structures in autoradiograms of brain sections. These results show that quantitative autoradiography can be used to characterize the local metabolism of antiviral drugs by infected cells in vivo. They also suggest that the selective uptake of drugs that exploit viral thymidine kinase for their antiviral effect can, by appropriate labeling, be used in conjunction with clinical neuroimaging techniques to define infected regions of human brain, thereby providing a new approach to the diagnosis of herpes encephalitis in man." @default.
• W2078125985 created "2016-06-24" @default.
• W2078125985 creator A5013809644 @default.
• W2078125985 creator A5027078344 @default.
• W2078125985 creator A5046786824 @default.
• W2078125985 creator A5069908505 @default.
• W2078125985 creator A5071035150 @default.
• W2078125985 creator A5083757871 @default.
• W2078125985 creator A5087440213 @default.
• W2078125985 date "1982-09-17" @default.
• W2078125985 modified "2023-10-11" @default.
• W2078125985 title "Quantitative Autoradiographic Mapping of Herpes Simplex Virus Encephalitis with a Radiolabeled Antiviral Drug" @default.
• W2078125985 cites W1892320270 @default.
• W2078125985 cites W2005141601 @default.
• W2078125985 cites W2008780004 @default.
• W2078125985 cites W2017826547 @default.
• W2078125985 cites W2021141393 @default.
• W2078125985 cites W2045360603 @default.
• W2078125985 cites W2057603161 @default.
• W2078125985 cites W2085149684 @default.
• W2078125985 cites W2090306035 @default.
• W2078125985 cites W2094811518 @default.
• W2078125985 cites W2103922065 @default.
• W2078125985 cites W2142992472 @default.
• W2078125985 cites W2333553600 @default.
• W2078125985 cites W2337976486 @default.
• W2078125985 cites W2418451262 @default.
• W2078125985 cites W4379790460 @default.
• W2078125985 doi "https://doi.org/10.1126/science.7112121" @default.
• W2078125985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7112121" @default.
• W2078125985 hasPublicationYear "1982" @default.
• W2078125985 type Work @default.
• W2078125985 sameAs 2078125985 @default.
• W2078125985 citedByCount "84" @default.
• W2078125985 countsByYear W20781259852012 @default.
• W2078125985 countsByYear W20781259852014 @default.
• W2078125985 countsByYear W20781259852021 @default.
• W2078125985 countsByYear W20781259852023 @default.
• W2078125985 crossrefType "journal-article" @default.
• W2078125985 hasAuthorship W2078125985A5013809644 @default.
• W2078125985 hasAuthorship W2078125985A5027078344 @default.
• W2078125985 hasAuthorship W2078125985A5046786824 @default.
• W2078125985 hasAuthorship W2078125985A5069908505 @default.
• W2078125985 hasAuthorship W2078125985A5071035150 @default.
• W2078125985 hasAuthorship W2078125985A5083757871 @default.
• W2078125985 hasAuthorship W2078125985A5087440213 @default.
• W2078125985 hasConcept C128102431 @default.
• W2078125985 hasConcept C150903083 @default.
• W2078125985 hasConcept C159047783 @default.
• W2078125985 hasConcept C159654299 @default.
• W2078125985 hasConcept C203014093 @default.
• W2078125985 hasConcept C207001950 @default.
• W2078125985 hasConcept C2522874641 @default.
• W2078125985 hasConcept C2776147627 @default.
• W2078125985 hasConcept C2776409557 @default.
• W2078125985 hasConcept C2776543447 @default.
• W2078125985 hasConcept C2777108182 @default.
• W2078125985 hasConcept C2779756493 @default.
• W2078125985 hasConcept C2780727368 @default.
• W2078125985 hasConcept C2781196997 @default.
• W2078125985 hasConcept C542903549 @default.
• W2078125985 hasConcept C552990157 @default.
• W2078125985 hasConcept C55493867 @default.
• W2078125985 hasConcept C83455156 @default.
• W2078125985 hasConcept C86803240 @default.
• W2078125985 hasConceptScore W2078125985C128102431 @default.
• W2078125985 hasConceptScore W2078125985C150903083 @default.
• W2078125985 hasConceptScore W2078125985C159047783 @default.
• W2078125985 hasConceptScore W2078125985C159654299 @default.
• W2078125985 hasConceptScore W2078125985C203014093 @default.
• W2078125985 hasConceptScore W2078125985C207001950 @default.
• W2078125985 hasConceptScore W2078125985C2522874641 @default.
• W2078125985 hasConceptScore W2078125985C2776147627 @default.
• W2078125985 hasConceptScore W2078125985C2776409557 @default.
• W2078125985 hasConceptScore W2078125985C2776543447 @default.
• W2078125985 hasConceptScore W2078125985C2777108182 @default.
• W2078125985 hasConceptScore W2078125985C2779756493 @default.
• W2078125985 hasConceptScore W2078125985C2780727368 @default.
• W2078125985 hasConceptScore W2078125985C2781196997 @default.
• W2078125985 hasConceptScore W2078125985C542903549 @default.
• W2078125985 hasConceptScore W2078125985C552990157 @default.
• W2078125985 hasConceptScore W2078125985C55493867 @default.
• W2078125985 hasConceptScore W2078125985C83455156 @default.
• W2078125985 hasConceptScore W2078125985C86803240 @default.
• W2078125985 hasIssue "4565" @default.
• W2078125985 hasLocation W20781259851 @default.
• W2078125985 hasOpenAccess W2078125985 @default.
• W2078125985 hasPrimaryLocation W20781259851 @default.
• W2078125985 hasRelatedWork W1608224135 @default.
• W2078125985 hasRelatedWork W1993107496 @default.
• W2078125985 hasRelatedWork W2007284859 @default.
• W2078125985 hasRelatedWork W2039434799 @default.
• W2078125985 hasRelatedWork W2080004714 @default.
• W2078125985 hasRelatedWork W2118837546 @default.
• W2078125985 hasRelatedWork W2324224710 @default.
• W2078125985 hasRelatedWork W2951991476 @default.
• W2078125985 hasRelatedWork W4239997277 @default.
• W2078125985 hasRelatedWork W2189544377 @default.

• next