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- W2078126475 endingPage "395" @default.
- W2078126475 startingPage "389" @default.
- W2078126475 abstract "Pituitary adenomas are the common neoplasms that cause mass effect and/or endocrine dysfunction. Studies in the pathogenesis and functional regulation of pituitary adenomas are mainly focused on the following two topics: (a) the origin of pituitary adenomas and abnormal physical adjustment due to the activation of oncogenes and loss of function for tumour-suppressor genes; and (b) the mechanistic anomalies of the intracellular signal transduction. Among which, the Raf/MEK/ERK signalling has been considered to be one of the major and central pathways in disease aetiology. Raf/MEK/ERK signalling is evolutionarily conserved that controls cellular growth, differentiation and survival. Altered functionality of this signalling pathway has been found to be involved in the development of several types of cancers in humans including pituitary adenomas. This review summarises the roles of Raf/MEK/ERK signalling pathway in pituitary tumourigenesis and highlights the clinical potential of this signalling pathways to be a therapeutic target for intervention and treatment of pituitary adenomas." @default.
- W2078126475 created "2016-06-24" @default.
- W2078126475 creator A5042089544 @default.
- W2078126475 creator A5047268659 @default.
- W2078126475 creator A5048887247 @default.
- W2078126475 creator A5088973373 @default.
- W2078126475 date "2012-02-01" @default.
- W2078126475 modified "2023-10-15" @default.
- W2078126475 title "Targeting Raf/MEK/ERK pathway in pituitary adenomas" @default.
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