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• W2078127962 abstract "The zinc finger E-box binding protein 1 (ZEB1) transcription factor belongs to a two-member family of zinc-finger homeodomain proteins involved in physiological and pathological events mostly relating to cell migration and epithelial to mesenchymal transitions (EMTs). ZEB1 (also known as δEF1, zfhx1a, TCF8, and Zfhep) plays a key role in regulating such diverse processes as T-cell development, skeletal patterning, reproduction, and cancer cell metastasis. However, the factors that regulate its expression and consequently the signaling pathways in which ZEB1 participates are poorly defined. Because it is induced by estrogen and progesterone and is high in prostate cancer, we investigated whether tcf8, which encodes ZEB1, is regulated by androgen. Data herein demonstrate that tcf8 is induced by dihydrotestosterone (DHT) in the human PC-3/AR prostate cancer cell line and that this induction is mediated by two androgen response elements (AREs). These results demonstrate that ZEB1 is an intermediary in androgen signaling pathways." @default.
• W2078127962 created "2016-06-24" @default.
• W2078127962 creator A5083899686 @default.
• W2078127962 creator A5088386075 @default.
• W2078127962 date "2011-01-01" @default.
• W2078127962 modified "2023-10-12" @default.
• W2078127962 title "Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor" @default.
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• W2078127962 doi "https://doi.org/10.1155/2011/903918" @default.
• W2078127962 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3235469" @default.
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