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• W2078128302 abstract "DNA adenine methylase (Dam(-)) mutants of Salmonella enterica are attenuated in the mouse model and present multiple virulence-related defects. Impaired interaction of Salmonella Dam(-) mutants with the intestinal epithelium has been tentatively correlated with reduced secretion of pathogenicity island 1 (SPI-1) effectors. In this study, we show that S. enterica Dam(-) mutants contain lowered levels of the SPI-1 transcriptional regulators HilA, HilC, HilD, and InvF. Epistasis analysis indicates that Dam-dependent regulation of SPI-1 requires HilD, while HilA, HilC, and InvF are dispensable. A transcriptional hilDlac fusion is expressed at similar levels in Dam(+) and Dam(-) hosts. However, lower levels of hilD mRNA are found in a Dam(-) background, thus providing unsuspected evidence that Dam methylation might exert post-transcriptional regulation of hilD expression. This hypothesis is supported by the following lines of evidence: (i) lowered levels of hilD mRNA are found in Salmonella Dam(-) mutants when hilD is transcribed from a heterologous promoter; (ii) increased hilD mRNA turnover is observed in Dam(-) mutants; (iii) lack of the Hfq RNA chaperone enhances hilD mRNA instability in Dam(-) mutants; and (iv) lack of the RNA degradosome components polynucleotide phosphorylase and ribonuclease E suppresses hilD mRNA instability in a Dam(-) background. Our report of Dam-dependent control of hilD mRNA stability suggests that DNA adenine methylation plays hitherto unknown roles in post-transcriptional control of gene expression." @default.
• W2078128302 created "2016-06-24" @default.
• W2078128302 creator A5083158181 @default.
• W2078128302 creator A5087276344 @default.
• W2078128302 date "2010-03-01" @default.
• W2078128302 modified "2023-10-14" @default.
• W2078128302 title "Regulation of <i>Salmonella enterica</i> Pathogenicity Island 1 by DNA Adenine Methylation" @default.
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• W2078128302 doi "https://doi.org/10.1534/genetics.109.108985" @default.
• W2078128302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2845334" @default.
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