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- W207812929 abstract "Background: B-cell precursor acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Proto-oncogene MYC functions as a DNA binding transcriptional activator. BET family proteins facilitate MYC transcription, and have recently emerged as a potential therapeutic target in heamopoitic malignancies. JQl is a cell-permeable small molecule that binds competitively to the acetyl-lysine recognition motifs with high specificity for the bromodomains of BET family members, preventing their ability to transcribe MYC. JQI inhibitor bas previously demonstrated drastic anti-tumour activity in Vitro and in pre clinical models of c-Myc dependent malignancies. Aim: To investigate the sensitivity of ALL cells to JQI-mediated BET inhibition, and whether JQ1 is capable of sensitising cytotoxic agent Dexamethasone resistant ALL cells to Dexamethasone induced cell killing both in vitro and in vivo. Methods: Cytotoxicity assays were used to investigate JQl-mediated Dexamethasone sensitisation in ALL cells in vitro. A Xenograft model was used to investigate this in NOG mice in vivo.Results: JQl-dexamethasone co-treatment resulted insignificantly increased cell killing in vitro and complete tumour suppression in vivo. Discussion: JQl is capable of sensitising Dexamethasone resistant ALL cells to Dexamethasone induced cell killing both in vitro and in vivo." @default.
- W207812929 created "2016-06-24" @default.
- W207812929 creator A5054658589 @default.
- W207812929 date "2013-12-01" @default.
- W207812929 modified "2023-09-26" @default.
- W207812929 title "Project 1: Novel bromodomain and extra-terminal (BET) protein inhibitor JQ1 sensitises dexamethasone-resistant ALL cells to dexamethasone-induced cell killing and Does microRNA deregulation contribute to PTTGl-Binding Factor (PBF) overexpression in thyroid carcinoma? Project 2: Does microRNA deregulation contribute to PTTG1-Binding Factor (PBF) overexpression in thyroid carcinoma?" @default.
- W207812929 hasPublicationYear "2013" @default.
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