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- W2078130187 abstract "Since we are limited in our knowledge of human demographic history and variations of recombination and mutation rates, large-scale computer simulation is a necessary tool in genetics. Here we propose and computationally simulate a model of evolution for unique and segmentally duplicated regions of human genome. Since such segmentally duplicated regions show a complex behaviour of copy number changes, our model will hopefully lead to a better understanding of the evolutionary developments of CNVs, algorithms for associations studies with CNV markers, and finally, for characterising parameters for stochastic diffusion models, describing asymptotic behaviour of evolutionary processes." @default.
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- W2078130187 date "2010-01-01" @default.
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- W2078130187 title "On a novel coalescent model for genome-wide evolution of Copy Number Variations" @default.
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- W2078130187 doi "https://doi.org/10.1504/ijdmb.2010.033522" @default.
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