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• W2078132934 abstract "✓ The effects of prostaglandin D 2 (PGD 2 ) on the growth of mouse malignant glioma cells were studied in vitro and in vivo . The in vitro studies consisted of various concentrations of prostaglandins (PG's) being added to cultures of mouse glioma cells. At concentrations above 2.5 µ g/ml, PGD 2 strongly inhibited the proliferation of glioma cells, whereas PGE 2 had no effect at the same value. Exposure to 5.0 µ g/ml PGD 2 for more than 2 hours resulted in inhibition of glioma cell proliferation. This growth-inhibitory effect of PGD 2 was related to the inhibition of DNA synthesis of the cells. The in vivo studies were performed with a subcutaneously transplanted mouse glioma model. Injection of 0.5 mg/kg PGD 2 into the tumor was more effective than the same concentration given by intraperitoneal injection. In mice with intracranially transplanted glioma, daily intraperitoneal injection of 0.5 mg/kg PGD 2 had no significant effect on survival time." @default.
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• W2078132934 date "1984-11-01" @default.
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• W2078132934 title "Growth-inhibitory effect of prostaglandin D2 on mouse glioma cells" @default.
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• W2078132934 doi "https://doi.org/10.3171/jns.1984.61.5.0912" @default.
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