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- W2078133240 abstract "Type II diabetes and its complications are a tremendous health burden throughout the world. Our understanding of the changes that lead to glucose imbalance and insulin resistance and ultimately diabetes remain incompletely understood. Many signaling and transcriptional pathways have been identified as being important to maintain normal glucose balance, including that of the peroxisome proliferator activated receptor gamma coactivator (PGC-1) family. This family of transcriptional coactivators strongly regulates mitochondrial and metabolic biology in numerous organs. The use of genetic models of PGC-1s, including both tissue-specific overexpression and knock-out models, has helped to reveal the specific roles that these coactivators play in each tissue. This review will thus focus on the PGC-1s and recently developed genetic rodent models that have highlighted the importance of these molecules in maintaining normal glucose homeostasis." @default.
- W2078133240 created "2016-06-24" @default.
- W2078133240 creator A5007124467 @default.
- W2078133240 creator A5016992389 @default.
- W2078133240 date "2013-09-22" @default.
- W2078133240 modified "2023-10-17" @default.
- W2078133240 title "Genetic models of PGC-1 and glucose metabolism and homeostasis" @default.
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- W2078133240 doi "https://doi.org/10.1007/s11154-013-9273-5" @default.
- W2078133240 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3943760" @default.
- W2078133240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24057597" @default.
- W2078133240 hasPublicationYear "2013" @default.
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