Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078134073> ?p ?o ?g. }
- W2078134073 endingPage "849" @default.
- W2078134073 startingPage "841" @default.
- W2078134073 abstract "Aim Titanium wear particles have been found in peri-implant tissues, but their role in the pathogenesis of peri-implantitis remains unclear. We aimed to determine the in vitro inflammatory responses of peri-implant granulation tissue fibroblasts (PIGFs) to titanium particles alone and in the presence of viable Porphyromonas gingivalis. Materials & Methods Peri-implant granulation tissue fibroblasts were challenged either with TiO2 particles, P. gingivalis or a combination of TiO2 particles and P. gingivalis. Gene expression and protein production of pro-inflammatory mediators by PIGFs were measured with PCR and ELISA, respectively. Results Higher doses of TiO2 were toxic to PIGFs and in sub-toxic doses, TiO2 caused an increase in gene expression of tumour necrosis factor (TNF)-A and increased protein production of TNF-α, interleukin (IL)-6 and IL-8. A challenge with P. gingivalis alone induced gene expression of TNF-A, IL-1β, IL-6 and IL-8. A combined challenge with TiO2 and P. gingivalis caused a stronger increase in gene expression of TNF-A and protein production of TNF-α and MCP-1 than P. gingivalis alone. Conclusions TiO2 particles and P. gingivalis, individually, can induce pro-inflammatory responses in PIGFs. Furthermore, TiO2 particles and viable P. gingivalis further enhance gene expression and production of TNF-α by PIGFs. Therefore, Ti wear particles in the peri-implant tissues in combination with P. gingivalis infection may contribute to the pathogenesis of peri-implantitis by enhancing the inflammation in peri-implant tissues." @default.
- W2078134073 created "2016-06-24" @default.
- W2078134073 creator A5001476429 @default.
- W2078134073 creator A5005306754 @default.
- W2078134073 creator A5023549382 @default.
- W2078134073 creator A5034246888 @default.
- W2078134073 creator A5051168583 @default.
- W2078134073 creator A5052515042 @default.
- W2078134073 date "2013-07-22" @default.
- W2078134073 modified "2023-09-26" @default.
- W2078134073 title "Influence of titanium on in vitro fibroblast-<i>Porphyromonas gingivalis</i> interaction in peri-implantitis" @default.
- W2078134073 cites W1580022062 @default.
- W2078134073 cites W1581103454 @default.
- W2078134073 cites W1918427796 @default.
- W2078134073 cites W1970269546 @default.
- W2078134073 cites W1972296986 @default.
- W2078134073 cites W1974670582 @default.
- W2078134073 cites W1999714531 @default.
- W2078134073 cites W2004589717 @default.
- W2078134073 cites W2008378818 @default.
- W2078134073 cites W2015891571 @default.
- W2078134073 cites W2017735436 @default.
- W2078134073 cites W2029995817 @default.
- W2078134073 cites W2033423153 @default.
- W2078134073 cites W2034306778 @default.
- W2078134073 cites W2042573744 @default.
- W2078134073 cites W2043248182 @default.
- W2078134073 cites W2043258360 @default.
- W2078134073 cites W2044379152 @default.
- W2078134073 cites W2050563255 @default.
- W2078134073 cites W2057298138 @default.
- W2078134073 cites W2058443443 @default.
- W2078134073 cites W2062398597 @default.
- W2078134073 cites W2078844869 @default.
- W2078134073 cites W2080782005 @default.
- W2078134073 cites W2081405343 @default.
- W2078134073 cites W2084638165 @default.
- W2078134073 cites W2084751257 @default.
- W2078134073 cites W2085902590 @default.
- W2078134073 cites W2095351559 @default.
- W2078134073 cites W2099814449 @default.
- W2078134073 cites W2109545700 @default.
- W2078134073 cites W2112880786 @default.
- W2078134073 cites W2122962788 @default.
- W2078134073 cites W2127407685 @default.
- W2078134073 cites W2129535314 @default.
- W2078134073 cites W2132421491 @default.
- W2078134073 cites W2132761521 @default.
- W2078134073 cites W2134326990 @default.
- W2078134073 cites W2138546131 @default.
- W2078134073 cites W2144715202 @default.
- W2078134073 cites W2147222520 @default.
- W2078134073 cites W2152389870 @default.
- W2078134073 cites W2152409544 @default.
- W2078134073 cites W2156806286 @default.
- W2078134073 cites W2157531458 @default.
- W2078134073 cites W2160538792 @default.
- W2078134073 cites W2160551611 @default.
- W2078134073 cites W2163744923 @default.
- W2078134073 cites W2164068463 @default.
- W2078134073 cites W2168874564 @default.
- W2078134073 doi "https://doi.org/10.1111/jcpe.12136" @default.
- W2078134073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23875835" @default.
- W2078134073 hasPublicationYear "2013" @default.
- W2078134073 type Work @default.
- W2078134073 sameAs 2078134073 @default.
- W2078134073 citedByCount "44" @default.
- W2078134073 countsByYear W20781340732014 @default.
- W2078134073 countsByYear W20781340732015 @default.
- W2078134073 countsByYear W20781340732016 @default.
- W2078134073 countsByYear W20781340732017 @default.
- W2078134073 countsByYear W20781340732018 @default.
- W2078134073 countsByYear W20781340732019 @default.
- W2078134073 countsByYear W20781340732020 @default.
- W2078134073 countsByYear W20781340732021 @default.
- W2078134073 countsByYear W20781340732022 @default.
- W2078134073 countsByYear W20781340732023 @default.
- W2078134073 crossrefType "journal-article" @default.
- W2078134073 hasAuthorship W2078134073A5001476429 @default.
- W2078134073 hasAuthorship W2078134073A5005306754 @default.
- W2078134073 hasAuthorship W2078134073A5023549382 @default.
- W2078134073 hasAuthorship W2078134073A5034246888 @default.
- W2078134073 hasAuthorship W2078134073A5051168583 @default.
- W2078134073 hasAuthorship W2078134073A5052515042 @default.
- W2078134073 hasConcept C104317684 @default.
- W2078134073 hasConcept C141071460 @default.
- W2078134073 hasConcept C150194340 @default.
- W2078134073 hasConcept C17991360 @default.
- W2078134073 hasConcept C185592680 @default.
- W2078134073 hasConcept C199343813 @default.
- W2078134073 hasConcept C202751555 @default.
- W2078134073 hasConcept C203014093 @default.
- W2078134073 hasConcept C2776055305 @default.
- W2078134073 hasConcept C2776914184 @default.
- W2078134073 hasConcept C2780183776 @default.
- W2078134073 hasConcept C2780269544 @default.
- W2078134073 hasConcept C2780381497 @default.
- W2078134073 hasConcept C2780385504 @default.