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- W2078134150 abstract "Epithelial-to-mesenchymal transition (EMT) is a process that plays essential roles in development and wound healing that is characterized by loss of homotypic adhesion and cell polarity and increased invasion and migration. At the molecular level, EMT is characterized by loss of E-cadherin and increased expression of several transcriptional repressors of E-cadherin expression (Zeb-1, Zeb-2, Twist, Snail, and Slug). Early work established that loss of E-cadherin and increased expression of MMP-9 was associated with a poor clinical outcome in patients with urothelial tumors, suggesting that EMT might also be associated with bladder cancer progression and metastasis. More recently, we have used global gene expression profiling to characterize the molecular heterogeneity in human urothelial cancer cell lines (n = 20) and primary patient tumors, and unsupervised clustering analyses revealed that the cells naturally segregate into two discrete epithelial and mesenchymal subsets, the latter consisting entirely of muscle-invasive tumors. Importantly, sensitivity to inhibitors of the epidermal growth factor receptor (EGFR) or type-3 fibroblast growth factor receptor (FGFR3) was confined to the epithelial subset, and sensitivity to EGFR inhibitors could be reestablished by micro-RNA-mediated molecular reversal of EMT. The results suggest that EMT coordinately regulates drug resistance and muscle invasion/metastasis in urothelial cancer and is a dominant feature of overall cancer biology." @default.
- W2078134150 created "2016-06-24" @default.
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- W2078134150 date "2009-12-01" @default.
- W2078134150 modified "2023-09-30" @default.
- W2078134150 title "Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer" @default.
- W2078134150 cites W1964006210 @default.
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- W2078134150 cites W1976324983 @default.
- W2078134150 cites W1978177843 @default.
- W2078134150 cites W1979964110 @default.
- W2078134150 cites W1982574859 @default.
- W2078134150 cites W1984145333 @default.
- W2078134150 cites W1992478375 @default.
- W2078134150 cites W1996239347 @default.
- W2078134150 cites W2004611919 @default.
- W2078134150 cites W2013183753 @default.
- W2078134150 cites W2014691022 @default.
- W2078134150 cites W2015351042 @default.
- W2078134150 cites W2017343980 @default.
- W2078134150 cites W2019408938 @default.
- W2078134150 cites W2023741846 @default.
- W2078134150 cites W2025647419 @default.
- W2078134150 cites W2028586185 @default.
- W2078134150 cites W2031142145 @default.
- W2078134150 cites W2036801235 @default.
- W2078134150 cites W2039805273 @default.
- W2078134150 cites W2040767945 @default.
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- W2078134150 cites W2065146309 @default.
- W2078134150 cites W2069719383 @default.
- W2078134150 cites W2070705072 @default.
- W2078134150 cites W2072894518 @default.
- W2078134150 cites W2077728054 @default.
- W2078134150 cites W2077850223 @default.
- W2078134150 cites W2078932376 @default.
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- W2078134150 cites W2093312816 @default.
- W2078134150 cites W2094400672 @default.
- W2078134150 cites W2095673635 @default.
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- W2078134150 cites W2131722060 @default.
- W2078134150 cites W2131831783 @default.
- W2078134150 cites W2131936396 @default.
- W2078134150 cites W2134989772 @default.
- W2078134150 cites W2136337672 @default.
- W2078134150 cites W2142850084 @default.
- W2078134150 cites W2143895308 @default.
- W2078134150 cites W2150507760 @default.
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- W2078134150 cites W2167430913 @default.
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- W2078134150 doi "https://doi.org/10.1007/s10555-009-9194-7" @default.
- W2078134150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5915353" @default.
- W2078134150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20012924" @default.
- W2078134150 hasPublicationYear "2009" @default.
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