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- W2078137300 abstract "Flavonoids have been extensively studied and are well documented to have anticancer effects, but it is not entirely known how they impact cellular mechanisms to elicit these effects. In the course of this study, we found that a variety of different flavonoids readily restored Brahma (BRM) in BRM-deficient cancer cell lines. Flavonoids from each of the six different structural groups were effective at inducing BRM expression as well as inhibiting growth in these BRM-deficient cancer cells. By blocking the induction of BRM with shRNA, we found that flavonoid-induced growth inhibition was BRM dependent. We also found that flavonoids can restore BRM functionality by reversing BRM acetylation. In addition, we observed that an array of natural flavonoid-containing products both induced BRM expression as well as deacetylated the BRM protein. We also tested two of the BRM-inducing flavonoids (Rutin and Diosmin) at both a low and a high dose on the development of tumors in an established murine lung cancer model. We found that these flavonoids effectively blocked development of adenomas in the lungs of wild-type mice but not in that of BRMnull mice. These data demonstrate that BRM expression and function are regulated by flavonoids and that functional BRM appears to be a prerequisite for the anticancer effects of flavonoids both in vitro and in vivo." @default.
- W2078137300 created "2016-06-24" @default.
- W2078137300 creator A5012420449 @default.
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- W2078137300 creator A5074948649 @default.
- W2078137300 creator A5087205210 @default.
- W2078137300 date "2014-05-29" @default.
- W2078137300 modified "2023-09-28" @default.
- W2078137300 title "Flavonoids from each of the six structural groups reactivate BRM, a possible cofactor for the anticancer effects of flavonoids" @default.
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- W2078137300 cites W1976903076 @default.
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- W2078137300 cites W1981283223 @default.
- W2078137300 cites W1984358846 @default.
- W2078137300 cites W1990408513 @default.
- W2078137300 cites W1994222503 @default.
- W2078137300 cites W2005439670 @default.
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- W2078137300 cites W2009904848 @default.
- W2078137300 cites W2010497399 @default.
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- W2078137300 cites W2012042113 @default.
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- W2078137300 cites W2038756571 @default.
- W2078137300 cites W2039189450 @default.
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- W2078137300 cites W2064255634 @default.
- W2078137300 cites W2064863361 @default.
- W2078137300 cites W2065315198 @default.
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- W2078137300 cites W2128108278 @default.
- W2078137300 cites W2128954527 @default.
- W2078137300 cites W2136582666 @default.
- W2078137300 cites W2139476591 @default.
- W2078137300 cites W2142463490 @default.
- W2078137300 cites W2144219918 @default.
- W2078137300 cites W2144603423 @default.
- W2078137300 cites W2145088924 @default.
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- W2078137300 cites W2329983604 @default.
- W2078137300 cites W4240013922 @default.
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- W2078137300 doi "https://doi.org/10.1093/carcin/bgu117" @default.
- W2078137300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4178464" @default.
- W2078137300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24876151" @default.
- W2078137300 hasPublicationYear "2014" @default.
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