Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078137434> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2078137434 endingPage "150" @default.
- W2078137434 startingPage "144" @default.
- W2078137434 abstract "The effect of isoprenaline on mechanical and electrical functions was studied in intact and denuded rat isolated pulmonary arteries. In intact blood vessels, isoprenaline-induced relaxation was significantly attenuated by acidification of buffer, presence of Ba2+ and/or ouabain. Isoprenaline produced hyperpolarisation of vascular muscle cells increasing Em from − 61.0± 0.44 (n = 190 cells) to − 70.0 ± 0.74 mV (n = 31 cells; mean ± SE). The latter effect was inhibited by acidification of buffer, tetraethylammonium (TEA), Ba2+ and/or ouabain. Isoprenaline-mediated relaxation was also significantly inhibited by the removal of endothelial cells. Acidification of buffer, or the presence of Ba2+, or ouabain alone did not result in further inhibition of relaxation to isoprenaline in denuded tissues. However, Ba2+ and ouabain combined caused further inhibition of the relaxant responses to isoprenaline in denuded tissues analogous to intact tissue. Combined Ba2+, TEA and ouabain also caused substantial inhibition of relaxant response to isoprenaline. Inclusion of Ba2+, TEA or ouabain in acidic buffer did not further inhibit relaxation to isoprenaline when compared to Ba2+, TEA and ouabain combined in regular buffer. Denudation of blood vessels resulted in a significant hyperpolarisation of vascular muscle (− 67.4 ± 0.35 mV; n = 195 cells) due to the activation of K channels and Na+/K+-ATPase. In denuded tissue, isoprenaline was unable to further increase Em (− 68.8 ± 0.44 mV n = 36). Isoprenaline-induced hyperpolarisation involves activation of K channels and Na+/K+-ATPase of smooth muscle cells possibly in parallel but mutually dependent on the presence of endothelial cells." @default.
- W2078137434 created "2016-06-24" @default.
- W2078137434 creator A5078975473 @default.
- W2078137434 creator A5085360231 @default.
- W2078137434 date "2010-09-01" @default.
- W2078137434 modified "2023-09-26" @default.
- W2078137434 title "Influence of endothelium on β-adrenoceptor-mediated mechanical and electrical functions in rat pulmonary artery" @default.
- W2078137434 cites W1966143879 @default.
- W2078137434 cites W1967978789 @default.
- W2078137434 cites W1977996398 @default.
- W2078137434 cites W1993783817 @default.
- W2078137434 cites W2005375764 @default.
- W2078137434 cites W2007578821 @default.
- W2078137434 cites W2018715433 @default.
- W2078137434 cites W2024483556 @default.
- W2078137434 cites W2024766715 @default.
- W2078137434 cites W2045278887 @default.
- W2078137434 cites W2052646823 @default.
- W2078137434 cites W2058337198 @default.
- W2078137434 cites W2060294721 @default.
- W2078137434 cites W2064489455 @default.
- W2078137434 cites W2065203161 @default.
- W2078137434 cites W2080596034 @default.
- W2078137434 cites W2094693829 @default.
- W2078137434 cites W2118033887 @default.
- W2078137434 cites W2138287499 @default.
- W2078137434 cites W2154780280 @default.
- W2078137434 cites W2171552504 @default.
- W2078137434 doi "https://doi.org/10.1016/j.vph.2010.05.005" @default.
- W2078137434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20570752" @default.
- W2078137434 hasPublicationYear "2010" @default.
- W2078137434 type Work @default.
- W2078137434 sameAs 2078137434 @default.
- W2078137434 citedByCount "7" @default.
- W2078137434 countsByYear W20781374342012 @default.
- W2078137434 countsByYear W20781374342014 @default.
- W2078137434 countsByYear W20781374342015 @default.
- W2078137434 countsByYear W20781374342017 @default.
- W2078137434 crossrefType "journal-article" @default.
- W2078137434 hasAuthorship W2078137434A5078975473 @default.
- W2078137434 hasAuthorship W2078137434A5085360231 @default.
- W2078137434 hasConcept C12554922 @default.
- W2078137434 hasConcept C126322002 @default.
- W2078137434 hasConcept C134018914 @default.
- W2078137434 hasConcept C178790620 @default.
- W2078137434 hasConcept C185592680 @default.
- W2078137434 hasConcept C24998067 @default.
- W2078137434 hasConcept C2776090920 @default.
- W2078137434 hasConcept C2779133857 @default.
- W2078137434 hasConcept C2779395532 @default.
- W2078137434 hasConcept C2781295685 @default.
- W2078137434 hasConcept C2992686903 @default.
- W2078137434 hasConcept C4141045 @default.
- W2078137434 hasConcept C517785266 @default.
- W2078137434 hasConcept C537181965 @default.
- W2078137434 hasConcept C71924100 @default.
- W2078137434 hasConcept C86803240 @default.
- W2078137434 hasConceptScore W2078137434C12554922 @default.
- W2078137434 hasConceptScore W2078137434C126322002 @default.
- W2078137434 hasConceptScore W2078137434C134018914 @default.
- W2078137434 hasConceptScore W2078137434C178790620 @default.
- W2078137434 hasConceptScore W2078137434C185592680 @default.
- W2078137434 hasConceptScore W2078137434C24998067 @default.
- W2078137434 hasConceptScore W2078137434C2776090920 @default.
- W2078137434 hasConceptScore W2078137434C2779133857 @default.
- W2078137434 hasConceptScore W2078137434C2779395532 @default.
- W2078137434 hasConceptScore W2078137434C2781295685 @default.
- W2078137434 hasConceptScore W2078137434C2992686903 @default.
- W2078137434 hasConceptScore W2078137434C4141045 @default.
- W2078137434 hasConceptScore W2078137434C517785266 @default.
- W2078137434 hasConceptScore W2078137434C537181965 @default.
- W2078137434 hasConceptScore W2078137434C71924100 @default.
- W2078137434 hasConceptScore W2078137434C86803240 @default.
- W2078137434 hasFunder F4320334593 @default.
- W2078137434 hasIssue "3-4" @default.
- W2078137434 hasLocation W20781374341 @default.
- W2078137434 hasLocation W20781374342 @default.
- W2078137434 hasOpenAccess W2078137434 @default.
- W2078137434 hasPrimaryLocation W20781374341 @default.
- W2078137434 hasRelatedWork W1986988602 @default.
- W2078137434 hasRelatedWork W1990230662 @default.
- W2078137434 hasRelatedWork W2002370318 @default.
- W2078137434 hasRelatedWork W2038401625 @default.
- W2078137434 hasRelatedWork W2078137434 @default.
- W2078137434 hasRelatedWork W2091112795 @default.
- W2078137434 hasRelatedWork W2091701022 @default.
- W2078137434 hasRelatedWork W2154549936 @default.
- W2078137434 hasRelatedWork W2411811122 @default.
- W2078137434 hasRelatedWork W2412951423 @default.
- W2078137434 hasVolume "53" @default.
- W2078137434 isParatext "false" @default.
- W2078137434 isRetracted "false" @default.
- W2078137434 magId "2078137434" @default.
- W2078137434 workType "article" @default.