FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078143148> ?p ?o ?g. }

• W2078143148 endingPage "406" @default.
• W2078143148 startingPage "395" @default.
• W2078143148 abstract "Parkinson’s disease (PD) is a progressive neurological disorder for which, at present, there is no cure. Current therapy is largely based on the use of dopamine agonists and dopamine replacement therapy, designed to control the signs and symptoms of the disease. The majority of current treatments are administered in tablet form and can involve multiple daily doses, which may contribute to sub-optimal compliance. Previous studies with small groups of patients suggest that non-compliance with treatment can result in poor response to therapy and may ultimately increase direct and indirect healthcare costs. To determine the extent of non-compliance within the general PD population in the USA as well as the patient characteristics and healthcare costs associated with compliance and non-compliance. A retrospective analysis from a managed care perspective was conducted using data from the USA PharMetrics patient-centric claims database. PharMetrics claims data were complete from 31 December 2005 to 31 December 2009. Patients were included if they had at least two diagnoses for PD between 31 December 2005 and 31 December 2008, were older than 18 years of age, were continuously enrolled for at least 12 months after the date of the most recent PD diagnosis, and had no missing or invalid data. The follow-up period was the most recent 12-month block of continuous enrollment that occurred between 2006 and 2009. Patients were required to have at least one PD-related prescription within the follow-up period. The medication possession ratio (MPR) was used to categorise patients as compliant or non-compliant. Direct all-cause annual healthcare costs for patients with PD were estimated for each patient, and regression analyses were conducted to determine predictors for non-compliance. A total of 15,846 patients were included, of whom 46 % were considered to be non-compliant with their prescribed medication (MPR <0.8). Predictors of non-compliance included prescription of a medication administered in multiple daily doses (p < 0.0001), a period of <2 years since the initial PD diagnosis (p = 0.0002), a diagnosis of gastrointestinal disorder (p < 0.0001), and a diagnosis of depression (p < 0.0001). Non-compliance was also found to be related to age, with a lower odds of non-compliance in patients aged 41–80 years than in patients aged ≥81 years (p < 0.05). Although total drug mean costs were higher for compliant patients than non-compliant patients (driven mainly by the cost of PD-related medications), the mean costs associated with emergency room and inpatient visits were higher for patients non-compliant with their prescribed medication. Overall, the total all-cause annual healthcare mean cost was lower for compliant ($77,499) than for non-compliant patients ($84,949; p < 0.0001). Non-compliance is prevalent within the general USA PD population and is associated with a recent PD diagnosis, certain comorbidities, and multiple daily treatment dosing. Non-compliance may increase the burden on the healthcare system because of greater resource usage compared with the compliant population. Treatments that require fewer daily doses may have the potential to improve compliance, which in turn could reduce the economic burden associated with PD." @default.
• W2078143148 created "2016-06-24" @default.
• W2078143148 creator A5001402714 @default.
• W2078143148 creator A5002101784 @default.
• W2078143148 creator A5028436742 @default.
• W2078143148 creator A5074801897 @default.
• W2078143148 creator A5078275213 @default.
• W2078143148 date "2013-05-07" @default.
• W2078143148 modified "2023-10-04" @default.
• W2078143148 title "Compliance with Pharmacotherapy and Direct Healthcare Costs in Patients with Parkinson’s Disease: A Retrospective Claims Database Analysis" @default.
• W2078143148 cites W1424354897 @default.
• W2078143148 cites W1561072761 @default.
• W2078143148 cites W1993408885 @default.
• W2078143148 cites W2002975164 @default.
• W2078143148 cites W2005762357 @default.
• W2078143148 cites W2009217963 @default.
• W2078143148 cites W2011374528 @default.
• W2078143148 cites W2019309016 @default.
• W2078143148 cites W2019345253 @default.
• W2078143148 cites W2026860825 @default.
• W2078143148 cites W2031740174 @default.
• W2078143148 cites W2033231215 @default.
• W2078143148 cites W2036222770 @default.
• W2078143148 cites W2059522673 @default.
• W2078143148 cites W2062048315 @default.
• W2078143148 cites W2062586468 @default.
• W2078143148 cites W2069004548 @default.
• W2078143148 cites W2078819735 @default.
• W2078143148 cites W2093034785 @default.
• W2078143148 cites W2093388096 @default.
• W2078143148 cites W2111327231 @default.
• W2078143148 cites W2122224467 @default.
• W2078143148 cites W2136570995 @default.
• W2078143148 cites W2138405305 @default.
• W2078143148 cites W2142270985 @default.
• W2078143148 cites W2147982456 @default.
• W2078143148 cites W2151320291 @default.
• W2078143148 cites W2155114981 @default.
• W2078143148 cites W2160219101 @default.
• W2078143148 cites W2162860468 @default.
• W2078143148 cites W2322912881 @default.
• W2078143148 cites W2327573495 @default.
• W2078143148 cites W4211122169 @default.
• W2078143148 cites W4213329672 @default.
• W2078143148 cites W74091223 @default.
• W2078143148 doi "https://doi.org/10.1007/s40258-013-0033-1" @default.
• W2078143148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3717155" @default.
• W2078143148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23649891" @default.
• W2078143148 hasPublicationYear "2013" @default.
• W2078143148 type Work @default.
• W2078143148 sameAs 2078143148 @default.
• W2078143148 citedByCount "29" @default.
• W2078143148 countsByYear W20781431482012 @default.
• W2078143148 countsByYear W20781431482014 @default.
• W2078143148 countsByYear W20781431482015 @default.
• W2078143148 countsByYear W20781431482017 @default.
• W2078143148 countsByYear W20781431482018 @default.
• W2078143148 countsByYear W20781431482019 @default.
• W2078143148 countsByYear W20781431482020 @default.
• W2078143148 countsByYear W20781431482021 @default.
• W2078143148 countsByYear W20781431482022 @default.
• W2078143148 countsByYear W20781431482023 @default.
• W2078143148 crossrefType "journal-article" @default.
• W2078143148 hasAuthorship W2078143148A5001402714 @default.
• W2078143148 hasAuthorship W2078143148A5002101784 @default.
• W2078143148 hasAuthorship W2078143148A5028436742 @default.
• W2078143148 hasAuthorship W2078143148A5074801897 @default.
• W2078143148 hasAuthorship W2078143148A5078275213 @default.
• W2078143148 hasBestOaLocation W20781431481 @default.
• W2078143148 hasConcept C126322002 @default.
• W2078143148 hasConcept C137992405 @default.
• W2078143148 hasConcept C138816342 @default.
• W2078143148 hasConcept C159110408 @default.
• W2078143148 hasConcept C160735492 @default.
• W2078143148 hasConcept C162324750 @default.
• W2078143148 hasConcept C167135981 @default.
• W2078143148 hasConcept C177713679 @default.
• W2078143148 hasConcept C187212893 @default.
• W2078143148 hasConcept C2426938 @default.
• W2078143148 hasConcept C2776738588 @default.
• W2078143148 hasConcept C2779134260 @default.
• W2078143148 hasConcept C2908647359 @default.
• W2078143148 hasConcept C41008148 @default.
• W2078143148 hasConcept C500440147 @default.
• W2078143148 hasConcept C50522688 @default.
• W2078143148 hasConcept C524218345 @default.
• W2078143148 hasConcept C71924100 @default.
• W2078143148 hasConcept C77088390 @default.
• W2078143148 hasConcept C98274493 @default.
• W2078143148 hasConcept C99454951 @default.
• W2078143148 hasConceptScore W2078143148C126322002 @default.
• W2078143148 hasConceptScore W2078143148C137992405 @default.
• W2078143148 hasConceptScore W2078143148C138816342 @default.
• W2078143148 hasConceptScore W2078143148C159110408 @default.
• W2078143148 hasConceptScore W2078143148C160735492 @default.
• W2078143148 hasConceptScore W2078143148C162324750 @default.
• W2078143148 hasConceptScore W2078143148C167135981 @default.
• W2078143148 hasConceptScore W2078143148C177713679 @default.

• next