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- W2078143586 abstract "Commensal lactobacilli that produce hydrogen peroxide (H2O2) inhibit Neisseria gonorrhoeae in vitro, and clinical data suggest that they are associated with a reduced risk of gonorrhea. We precolonized mice with Lactobacillus crispatus and then challenged them with N. gonorrhoeae to measure the effects of H2O2-producing lactobacilli on gonococcal infection. We found no difference in the duration of infection or the number of gonococci recovered from untreated mice and mice colonized with L. crispatus A gonococcal catalase mutant and a catalase, cytochrome C peroxidase mutant exhibited greater susceptibility to L. crispatus in vitro than did wild-type bacteria; however, recovery of these mutants from mice was not affected by L. crispatus We also found no evidence that utilization of lactobacillus-produced lactate by N. gonorrhoeae balances the detrimental effects of H2O2 during infection. We conclude that the association between lactobacilli and gonococci is complex and may be subject to factors that have not been reproduced in vitro" @default.
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- W2078143586 date "2009-05-01" @default.
- W2078143586 modified "2023-10-12" @default.
- W2078143586 title "Hydrogen Peroxide–Producing Lactobacilli Inhibit Gonococci In Vitro but Not during Experimental Genital Tract Infection" @default.
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- W2078143586 doi "https://doi.org/10.1086/597390" @default.
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