FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078147619> ?p ?o ?g. }

• W2078147619 endingPage "531" @default.
• W2078147619 startingPage "526" @default.
• W2078147619 abstract "Tissue protein hypercatabolism (TPH) is an important feature in cancer cachexia, particularly with regard to the skeletal muscle. The Yoshida AH-130 rat ascites hepatoma is a model system for studying the mechanisms involved in the processes that lead to tissue depletion, since it induces in the host a rapid and progressive muscle wasting, primarily due to TPH. The present study was aimed at investigating if IL-15, which is known to favour muscle fibre hypertrophy, could antagonize the enhanced muscle protein breakdown in this cancer cachexia model. Indeed, IL-15 treatment partly inhibited skeletal muscle wasting in AH-130-bearing rats by decreasing (8-fold) protein degradative rates (as measured by 14C-bicarbonate pre-loading of muscle proteins) to values even lower than those observed in non-tumour-bearing animals. These alterations in protein breakdown rates were associated with an inhibition of the ATP-ubiquitin-dependent proteolytic pathway (35% and 41% for 2.4 and 1.2 kb ubiquitin mRNA, and 57% for the C8 proteasome subunit, respectively). The cytokine did not modify the plasma levels of corticosterone and insulin in the tumour hosts. The present data give new insights into the mechanisms by which IL-15 exerts its preventive effect on muscle protein wasting and seem to warrant the implementation of experimental protocols involving the use of the cytokine in the treatment of pathological states characterized by TPH, particularly in skeletal muscle, such as in the present model of cancer cachexia." @default.
• W2078147619 created "2016-06-24" @default.
• W2078147619 creator A5005897976 @default.
• W2078147619 creator A5006447314 @default.
• W2078147619 creator A5012215362 @default.
• W2078147619 creator A5019754590 @default.
• W2078147619 creator A5048204665 @default.
• W2078147619 creator A5061595191 @default.
• W2078147619 creator A5067995365 @default.
• W2078147619 creator A5068649483 @default.
• W2078147619 creator A5068748345 @default.
• W2078147619 date "2000-08-01" @default.
• W2078147619 modified "2023-10-17" @default.
• W2078147619 title "Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats" @default.
• W2078147619 cites W103399905 @default.
• W2078147619 cites W106370701 @default.
• W2078147619 cites W121090089 @default.
• W2078147619 cites W1487210663 @default.
• W2078147619 cites W1533477256 @default.
• W2078147619 cites W1549700502 @default.
• W2078147619 cites W1566443303 @default.
• W2078147619 cites W1567604499 @default.
• W2078147619 cites W1608783988 @default.
• W2078147619 cites W1772198037 @default.
• W2078147619 cites W1862877865 @default.
• W2078147619 cites W1869169988 @default.
• W2078147619 cites W1971875639 @default.
• W2078147619 cites W1972892862 @default.
• W2078147619 cites W1975047479 @default.
• W2078147619 cites W1981073876 @default.
• W2078147619 cites W1998790265 @default.
• W2078147619 cites W1999774015 @default.
• W2078147619 cites W2000979284 @default.
• W2078147619 cites W2006073656 @default.
• W2078147619 cites W2006413921 @default.
• W2078147619 cites W2007392443 @default.
• W2078147619 cites W2009925504 @default.
• W2078147619 cites W2035756845 @default.
• W2078147619 cites W2037070751 @default.
• W2078147619 cites W2046662379 @default.
• W2078147619 cites W2052161423 @default.
• W2078147619 cites W2057365575 @default.
• W2078147619 cites W2058860008 @default.
• W2078147619 cites W2065681494 @default.
• W2078147619 cites W2068122289 @default.
• W2078147619 cites W2069590093 @default.
• W2078147619 cites W2078508483 @default.
• W2078147619 cites W2084105573 @default.
• W2078147619 cites W2090912065 @default.
• W2078147619 cites W2092943957 @default.
• W2078147619 cites W2102314850 @default.
• W2078147619 cites W2125010485 @default.
• W2078147619 cites W2125221851 @default.
• W2078147619 cites W2127173129 @default.
• W2078147619 cites W2128635872 @default.
• W2078147619 cites W2134644835 @default.
• W2078147619 cites W2134812217 @default.
• W2078147619 cites W2142153547 @default.
• W2078147619 cites W2146787115 @default.
• W2078147619 cites W2166297867 @default.
• W2078147619 cites W2279880151 @default.
• W2078147619 cites W2398141765 @default.
• W2078147619 cites W2422350453 @default.
• W2078147619 cites W4245058170 @default.
• W2078147619 cites W5484105 @default.
• W2078147619 cites W2065236650 @default.
• W2078147619 doi "https://doi.org/10.1054/bjoc.2000.1299" @default.
• W2078147619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2374658" @default.
• W2078147619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10945502" @default.
• W2078147619 hasPublicationYear "2000" @default.
• W2078147619 type Work @default.
• W2078147619 sameAs 2078147619 @default.
• W2078147619 citedByCount "156" @default.
• W2078147619 countsByYear W20781476192012 @default.
• W2078147619 countsByYear W20781476192013 @default.
• W2078147619 countsByYear W20781476192014 @default.
• W2078147619 countsByYear W20781476192015 @default.
• W2078147619 countsByYear W20781476192016 @default.
• W2078147619 countsByYear W20781476192017 @default.
• W2078147619 countsByYear W20781476192018 @default.
• W2078147619 countsByYear W20781476192019 @default.
• W2078147619 countsByYear W20781476192020 @default.
• W2078147619 countsByYear W20781476192021 @default.
• W2078147619 countsByYear W20781476192022 @default.
• W2078147619 countsByYear W20781476192023 @default.
• W2078147619 crossrefType "journal-article" @default.
• W2078147619 hasAuthorship W2078147619A5005897976 @default.
• W2078147619 hasAuthorship W2078147619A5006447314 @default.
• W2078147619 hasAuthorship W2078147619A5012215362 @default.
• W2078147619 hasAuthorship W2078147619A5019754590 @default.
• W2078147619 hasAuthorship W2078147619A5048204665 @default.
• W2078147619 hasAuthorship W2078147619A5061595191 @default.
• W2078147619 hasAuthorship W2078147619A5067995365 @default.
• W2078147619 hasAuthorship W2078147619A5068649483 @default.
• W2078147619 hasAuthorship W2078147619A5068748345 @default.
• W2078147619 hasBestOaLocation W20781476191 @default.
• W2078147619 hasConcept C121608353 @default.
• W2078147619 hasConcept C126322002 @default.

• next