Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078148509> ?p ?o ?g. }
- W2078148509 abstract "Rat liver cytosol converted phenyloxirane enantiomers regioselectively to glutathione S-conjugates. R-(+)-Phenyloxirane was converted to S-(1-phenyl-2-hydroxyethyl)glutathione (conjugate 1) and S-(2-phenyl-2-hydroxyethyl)glutathione (conjugate 2) (ratio 6.1:1), and S-(-)-phenyloxirane to conjugates 1 and 2 (ratio 1:32). Racemic phenyloxirane was converted to conjugates 1 and 2 (ratio 1.8:1). The conjugates were separated by HPLC on an octadecylsilicone column and identified with synthetic specimens whose structures were assigned by 13C NMR spectrometry. R-(+)-, S-(-)- and racemic phenyloxiranes were hydrolyzed to R-(-)-, S-(+)- and racemic phenylethanediols by microsomal epoxide hydrolase without inversion of absolute configurations of their benzylic carbons. R-(+)-Phenyloxirane had much smaller Km and Vmax than the S-(-)-oxirane did. The R-(+)-oxirane potentially inhibited the microsomal hydrolysis of the S-(-)-oxirane and was preferentially hydrolyzed when the racemic oxirane was used as the substrate. Microsomal monooxygenase oxidized styrene to R-(+)- and S-(-)-phenyloxiranes (ratio 1.3:1), and the ratio was little changed by the pretreatment of the animal with phenobarbital, 3-methylcholanthrene and polychlorinated biphenyls." @default.
- W2078148509 created "2016-06-24" @default.
- W2078148509 creator A5021151911 @default.
- W2078148509 creator A5037161754 @default.
- W2078148509 creator A5066402317 @default.
- W2078148509 date "1983-03-01" @default.
- W2078148509 modified "2023-09-26" @default.
- W2078148509 title "Studies on metabolism and toxicity of styrene—VI. Regioselectivity in glutathione S-conjugation and hydrolysis of racemic, R- and S-phenyloxiranes in rat liver" @default.
- W2078148509 cites W1519710405 @default.
- W2078148509 cites W1520633498 @default.
- W2078148509 cites W1571118321 @default.
- W2078148509 cites W1775749144 @default.
- W2078148509 cites W1963958247 @default.
- W2078148509 cites W1967242985 @default.
- W2078148509 cites W1975952381 @default.
- W2078148509 cites W1978308663 @default.
- W2078148509 cites W1982144123 @default.
- W2078148509 cites W1983729554 @default.
- W2078148509 cites W1986433238 @default.
- W2078148509 cites W1993987888 @default.
- W2078148509 cites W1998461385 @default.
- W2078148509 cites W2001916677 @default.
- W2078148509 cites W2004823653 @default.
- W2078148509 cites W2010806334 @default.
- W2078148509 cites W2011176046 @default.
- W2078148509 cites W2026743557 @default.
- W2078148509 cites W2028610734 @default.
- W2078148509 cites W2031897220 @default.
- W2078148509 cites W2035813299 @default.
- W2078148509 cites W2036538865 @default.
- W2078148509 cites W2039121008 @default.
- W2078148509 cites W2043830692 @default.
- W2078148509 cites W2049831116 @default.
- W2078148509 cites W2055397035 @default.
- W2078148509 cites W2057861835 @default.
- W2078148509 cites W2070562676 @default.
- W2078148509 cites W2073513478 @default.
- W2078148509 cites W2075813223 @default.
- W2078148509 cites W2080663656 @default.
- W2078148509 cites W2088482345 @default.
- W2078148509 cites W2088761418 @default.
- W2078148509 cites W2090988405 @default.
- W2078148509 cites W2093822317 @default.
- W2078148509 cites W2094975031 @default.
- W2078148509 cites W21429993 @default.
- W2078148509 cites W2322637603 @default.
- W2078148509 cites W2335113673 @default.
- W2078148509 cites W2339621109 @default.
- W2078148509 cites W2402588272 @default.
- W2078148509 cites W2951638561 @default.
- W2078148509 cites W3005265399 @default.
- W2078148509 cites W4301860905 @default.
- W2078148509 doi "https://doi.org/10.1016/0006-2952(83)90576-2" @default.
- W2078148509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6838626" @default.
- W2078148509 hasPublicationYear "1983" @default.
- W2078148509 type Work @default.
- W2078148509 sameAs 2078148509 @default.
- W2078148509 citedByCount "41" @default.
- W2078148509 crossrefType "journal-article" @default.
- W2078148509 hasAuthorship W2078148509A5021151911 @default.
- W2078148509 hasAuthorship W2078148509A5037161754 @default.
- W2078148509 hasAuthorship W2078148509A5066402317 @default.
- W2078148509 hasConcept C101819947 @default.
- W2078148509 hasConcept C134306372 @default.
- W2078148509 hasConcept C178790620 @default.
- W2078148509 hasConcept C181199279 @default.
- W2078148509 hasConcept C185592680 @default.
- W2078148509 hasConcept C197336794 @default.
- W2078148509 hasConcept C33923547 @default.
- W2078148509 hasConcept C43617362 @default.
- W2078148509 hasConcept C486523 @default.
- W2078148509 hasConcept C538909803 @default.
- W2078148509 hasConcept C55493867 @default.
- W2078148509 hasConcept C62231903 @default.
- W2078148509 hasConcept C71240020 @default.
- W2078148509 hasConcept C87644729 @default.
- W2078148509 hasConcept C94412978 @default.
- W2078148509 hasConceptScore W2078148509C101819947 @default.
- W2078148509 hasConceptScore W2078148509C134306372 @default.
- W2078148509 hasConceptScore W2078148509C178790620 @default.
- W2078148509 hasConceptScore W2078148509C181199279 @default.
- W2078148509 hasConceptScore W2078148509C185592680 @default.
- W2078148509 hasConceptScore W2078148509C197336794 @default.
- W2078148509 hasConceptScore W2078148509C33923547 @default.
- W2078148509 hasConceptScore W2078148509C43617362 @default.
- W2078148509 hasConceptScore W2078148509C486523 @default.
- W2078148509 hasConceptScore W2078148509C538909803 @default.
- W2078148509 hasConceptScore W2078148509C55493867 @default.
- W2078148509 hasConceptScore W2078148509C62231903 @default.
- W2078148509 hasConceptScore W2078148509C71240020 @default.
- W2078148509 hasConceptScore W2078148509C87644729 @default.
- W2078148509 hasConceptScore W2078148509C94412978 @default.
- W2078148509 hasLocation W20781485091 @default.
- W2078148509 hasLocation W20781485092 @default.
- W2078148509 hasOpenAccess W2078148509 @default.
- W2078148509 hasPrimaryLocation W20781485091 @default.
- W2078148509 hasRelatedWork W1974735736 @default.
- W2078148509 hasRelatedWork W1981725126 @default.
- W2078148509 hasRelatedWork W2049717196 @default.
- W2078148509 hasRelatedWork W2050128107 @default.