Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078150511> ?p ?o ?g. }
- W2078150511 endingPage "1529" @default.
- W2078150511 startingPage "1517" @default.
- W2078150511 abstract "Antisense pharmaceutical research has sought to provide drugs that would yield effective therapies for diseases resulting from the production of deleterious proteins. The original concept was straightforward: eliminate production of unwanted proteins, such as oncogenic proteins, by blocking the function of their mRNAs; and block their mRNAs by adding “antisense” nucleic acids that bind them through complementary base pairing. However, it has proven difficult to develop clinically useful antisense strategies. Conventional antisense nucleic acids are large, highly charged, complex molecules that interact with a wide variety of unintended cellular and microbial components, often causing “nonantisense effects.” It is now clear that a broad knowledge of nucleic acid biochemistry will be needed to optimize antisense molecules for use in patients. The efficacy of naturally occurring antisense molecules and the success of antisense agricultural strategies prove that antisense approaches can be powerful and specific. Pharmaceutical antisense research can be expected to yield many valuable products once sufficient information about antisense mechanisms has been gathered and applied. This article explains the biochemical events that give rise to both antisense and nonantisense effects and provides guidelines for designing and evaluating antisense experiments." @default.
- W2078150511 created "2016-06-24" @default.
- W2078150511 creator A5010225017 @default.
- W2078150511 date "1996-12-01" @default.
- W2078150511 modified "2023-09-24" @default.
- W2078150511 title "A Hitchhiker's guide to antisense and nonantisense biochemical pathways" @default.
- W2078150511 cites W1502906266 @default.
- W2078150511 cites W1521901911 @default.
- W2078150511 cites W1534317756 @default.
- W2078150511 cites W1549105044 @default.
- W2078150511 cites W1567425707 @default.
- W2078150511 cites W1623759422 @default.
- W2078150511 cites W1646291673 @default.
- W2078150511 cites W1678644792 @default.
- W2078150511 cites W1678781278 @default.
- W2078150511 cites W1733933634 @default.
- W2078150511 cites W1836032532 @default.
- W2078150511 cites W1914838920 @default.
- W2078150511 cites W1924011861 @default.
- W2078150511 cites W1939078619 @default.
- W2078150511 cites W1945614554 @default.
- W2078150511 cites W1964852230 @default.
- W2078150511 cites W1965464174 @default.
- W2078150511 cites W1966648387 @default.
- W2078150511 cites W1968282235 @default.
- W2078150511 cites W1968987342 @default.
- W2078150511 cites W1969371329 @default.
- W2078150511 cites W1969411528 @default.
- W2078150511 cites W1969818257 @default.
- W2078150511 cites W1970650788 @default.
- W2078150511 cites W1971934078 @default.
- W2078150511 cites W1972147130 @default.
- W2078150511 cites W1975686151 @default.
- W2078150511 cites W1977698865 @default.
- W2078150511 cites W1980397164 @default.
- W2078150511 cites W1982848096 @default.
- W2078150511 cites W1988490108 @default.
- W2078150511 cites W1989794771 @default.
- W2078150511 cites W1992302499 @default.
- W2078150511 cites W1994540673 @default.
- W2078150511 cites W1994625920 @default.
- W2078150511 cites W1996063915 @default.
- W2078150511 cites W1997017839 @default.
- W2078150511 cites W1998281796 @default.
- W2078150511 cites W1999391211 @default.
- W2078150511 cites W1999545960 @default.
- W2078150511 cites W2004512784 @default.
- W2078150511 cites W2004537665 @default.
- W2078150511 cites W2004545420 @default.
- W2078150511 cites W2005333148 @default.
- W2078150511 cites W2006239014 @default.
- W2078150511 cites W2007404424 @default.
- W2078150511 cites W2011267456 @default.
- W2078150511 cites W2013659134 @default.
- W2078150511 cites W2014096646 @default.
- W2078150511 cites W2014457420 @default.
- W2078150511 cites W2015016710 @default.
- W2078150511 cites W2015638395 @default.
- W2078150511 cites W2015686762 @default.
- W2078150511 cites W2018429609 @default.
- W2078150511 cites W2021333801 @default.
- W2078150511 cites W2022846624 @default.
- W2078150511 cites W2027565750 @default.
- W2078150511 cites W2029276715 @default.
- W2078150511 cites W2029918421 @default.
- W2078150511 cites W2030799825 @default.
- W2078150511 cites W2030830487 @default.
- W2078150511 cites W2031092694 @default.
- W2078150511 cites W2036817211 @default.
- W2078150511 cites W2039257831 @default.
- W2078150511 cites W2046954253 @default.
- W2078150511 cites W2047366876 @default.
- W2078150511 cites W2047398077 @default.
- W2078150511 cites W2048688037 @default.
- W2078150511 cites W2050014764 @default.
- W2078150511 cites W2050072176 @default.
- W2078150511 cites W2052336952 @default.
- W2078150511 cites W2052732954 @default.
- W2078150511 cites W2055039476 @default.
- W2078150511 cites W2055492153 @default.
- W2078150511 cites W2055723458 @default.
- W2078150511 cites W2057445069 @default.
- W2078150511 cites W2057547665 @default.
- W2078150511 cites W2061687100 @default.
- W2078150511 cites W2063116879 @default.
- W2078150511 cites W2063192340 @default.
- W2078150511 cites W2063322107 @default.
- W2078150511 cites W2063915751 @default.
- W2078150511 cites W2065176243 @default.
- W2078150511 cites W2065458612 @default.
- W2078150511 cites W2066730127 @default.
- W2078150511 cites W2067214581 @default.
- W2078150511 cites W2067526724 @default.
- W2078150511 cites W2069981314 @default.
- W2078150511 cites W2072794717 @default.
- W2078150511 cites W2075165827 @default.
- W2078150511 cites W2076934212 @default.
- W2078150511 cites W2078238370 @default.