Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078153277> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2078153277 endingPage "1307" @default.
- W2078153277 startingPage "1301" @default.
- W2078153277 abstract "The endothelial lining and its outer lipid membrane are the first major barriers drug molecules encounter upon intravenous administration. Our previous work identified lipid analogs that counteract plasma membrane barrier function for a series of amphiphilic drugs. For example, short-chain sphingolipids (SCS), like N-octanoyl-glucosylceramide, effectively elevated doxorubicin accumulation in tumor cells, both in vitro and in vivo, and in endothelial cells, whereas other (normal) cells remained unaffected. We hypothesize here that local membrane lipid composition and the degree of lipid ordering define SCS efficacy in individual cells. To this end, we study the differential effect of SCS on bovine aortic endothelial cells (BAEC) in its confluent versus proliferative state, as a model system. While their (plasma membrane) lipidome stays remarkably unaltered when BAECs reach confluency, their lipids segregate to form apical and basolateral domains. Using probe NR12S, we reveal that lipids in the apical membrane are more condensed/liquid-ordered. SCS preferentially attenuate the barrier posed by these condensed membranes and facilitate doxorubicin influx in these particular membrane regions. We confirm these findings in MDCK cells and artificial membranes. In conclusion, SCS-facilitated drug traversal acts on condensed membrane domains, elicited by confluency in resting endothelium." @default.
- W2078153277 created "2016-06-24" @default.
- W2078153277 creator A5021658106 @default.
- W2078153277 creator A5041546307 @default.
- W2078153277 creator A5044517920 @default.
- W2078153277 creator A5079656735 @default.
- W2078153277 creator A5082971290 @default.
- W2078153277 creator A5086625921 @default.
- W2078153277 date "2014-09-01" @default.
- W2078153277 modified "2023-09-27" @default.
- W2078153277 title "Membrane organization determines barrier properties of endothelial cells and short-chain sphingolipid-facilitated doxorubicin influx" @default.
- W2078153277 cites W1536753629 @default.
- W2078153277 cites W1844745998 @default.
- W2078153277 cites W1975700906 @default.
- W2078153277 cites W1994127068 @default.
- W2078153277 cites W1999841301 @default.
- W2078153277 cites W2011078603 @default.
- W2078153277 cites W2012838605 @default.
- W2078153277 cites W2022514421 @default.
- W2078153277 cites W2028521809 @default.
- W2078153277 cites W2031576029 @default.
- W2078153277 cites W2044146758 @default.
- W2078153277 cites W2046425054 @default.
- W2078153277 cites W2059542108 @default.
- W2078153277 cites W2082432593 @default.
- W2078153277 cites W2087972720 @default.
- W2078153277 cites W2106508078 @default.
- W2078153277 cites W2107614619 @default.
- W2078153277 cites W2119731634 @default.
- W2078153277 cites W2125872855 @default.
- W2078153277 cites W2132770583 @default.
- W2078153277 cites W2157619122 @default.
- W2078153277 cites W2165836181 @default.
- W2078153277 cites W2171664179 @default.
- W2078153277 cites W2912349604 @default.
- W2078153277 doi "https://doi.org/10.1016/j.bbalip.2014.06.006" @default.
- W2078153277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24953779" @default.
- W2078153277 hasPublicationYear "2014" @default.
- W2078153277 type Work @default.
- W2078153277 sameAs 2078153277 @default.
- W2078153277 citedByCount "5" @default.
- W2078153277 countsByYear W20781532772014 @default.
- W2078153277 countsByYear W20781532772015 @default.
- W2078153277 countsByYear W20781532772017 @default.
- W2078153277 countsByYear W20781532772020 @default.
- W2078153277 countsByYear W20781532772022 @default.
- W2078153277 crossrefType "journal-article" @default.
- W2078153277 hasAuthorship W2078153277A5021658106 @default.
- W2078153277 hasAuthorship W2078153277A5041546307 @default.
- W2078153277 hasAuthorship W2078153277A5044517920 @default.
- W2078153277 hasAuthorship W2078153277A5079656735 @default.
- W2078153277 hasAuthorship W2078153277A5082971290 @default.
- W2078153277 hasAuthorship W2078153277A5086625921 @default.
- W2078153277 hasConcept C107565407 @default.
- W2078153277 hasConcept C12554922 @default.
- W2078153277 hasConcept C134018914 @default.
- W2078153277 hasConcept C185592680 @default.
- W2078153277 hasConcept C202751555 @default.
- W2078153277 hasConcept C2776992346 @default.
- W2078153277 hasConcept C41625074 @default.
- W2078153277 hasConcept C51911345 @default.
- W2078153277 hasConcept C55493867 @default.
- W2078153277 hasConcept C61705674 @default.
- W2078153277 hasConcept C86803240 @default.
- W2078153277 hasConcept C95444343 @default.
- W2078153277 hasConceptScore W2078153277C107565407 @default.
- W2078153277 hasConceptScore W2078153277C12554922 @default.
- W2078153277 hasConceptScore W2078153277C134018914 @default.
- W2078153277 hasConceptScore W2078153277C185592680 @default.
- W2078153277 hasConceptScore W2078153277C202751555 @default.
- W2078153277 hasConceptScore W2078153277C2776992346 @default.
- W2078153277 hasConceptScore W2078153277C41625074 @default.
- W2078153277 hasConceptScore W2078153277C51911345 @default.
- W2078153277 hasConceptScore W2078153277C55493867 @default.
- W2078153277 hasConceptScore W2078153277C61705674 @default.
- W2078153277 hasConceptScore W2078153277C86803240 @default.
- W2078153277 hasConceptScore W2078153277C95444343 @default.
- W2078153277 hasIssue "9" @default.
- W2078153277 hasLocation W20781532771 @default.
- W2078153277 hasLocation W20781532772 @default.
- W2078153277 hasLocation W20781532773 @default.
- W2078153277 hasOpenAccess W2078153277 @default.
- W2078153277 hasPrimaryLocation W20781532771 @default.
- W2078153277 hasRelatedWork W1973649841 @default.
- W2078153277 hasRelatedWork W2012197867 @default.
- W2078153277 hasRelatedWork W2044119772 @default.
- W2078153277 hasRelatedWork W2049114455 @default.
- W2078153277 hasRelatedWork W2062621103 @default.
- W2078153277 hasRelatedWork W2088393488 @default.
- W2078153277 hasRelatedWork W2771312017 @default.
- W2078153277 hasRelatedWork W2792213734 @default.
- W2078153277 hasRelatedWork W4240776407 @default.
- W2078153277 hasRelatedWork W4318960514 @default.
- W2078153277 hasVolume "1841" @default.
- W2078153277 isParatext "false" @default.
- W2078153277 isRetracted "false" @default.
- W2078153277 magId "2078153277" @default.
- W2078153277 workType "article" @default.