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• W2078153457 endingPage "957" @default.
• W2078153457 startingPage "951" @default.
• W2078153457 abstract "While opioid agonists administered into the hypothalamic paraventricular nucleus increase food intake in rats, naloxone reduces deprivation-induced intake. Ventricular administration of either mu (beta-funaltrexamine) or kappa (nor-binaltorphamine) opioid antagonists reduces spontaneous, deprivation, glucoprivic and palatable intake. The present study assessed whether microinjections of either general, mu or kappa opioid antagonists into the paraventricular nucleus altered either deprivation (24 h) intake, 2-deoxy-d-glucose hyperphagia or sucrose intake in rats. Deprivation intake was significantly reduced by nor-binaltorphamine (5 μg, 68 nmol, 30–33%), beta-funaltrexamine (5 μg, 100 nmol, 26–29%) or naltrexone (10 μg, 260 nmol, 26%) in the paraventricular nucleus. 2-Deoxy-d-glucose hyperphagia was significantly reduced only after 2 h by naltrexone (10 μg, 260 nmol, 69%), norbinaltorphamine (20 μg, 272 nmol, 69%) or beta-funaltrexamine (20 μg, 400 nmol, 83%) in the paraventricular nucleus. Sucrose intake was significantly reduced by nor-binaltorphamine (5 μg, 68 nmol, 27–36%), naltrexone (5–10 μg, 130–260 nmol, 18–31%) and beta-funaltrexamine (5 μg, 100 nmol, 20%) in the paraventricular nucleus. These data indicate that general, mu and kappa opioid antagonists administered into the hypothalamic paraventricular nucleus produce similar patterns of effects upon different forms of food intake as did ventricular administration, implicating this nucleus as part of the circuitry underlying opioid mediation of ingestion." @default.
• W2078153457 created "2016-06-24" @default.
• W2078153457 creator A5000400489 @default.
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• W2078153457 date "1995-06-01" @default.
• W2078153457 modified "2023-10-03" @default.
• W2078153457 title "Alterations in deprivation, glucoprivic and sucrose intake following general, mu and kappa opioid antagonists in the hypothalamic paraventricular nucleus of rats" @default.
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• W2078153457 doi "https://doi.org/10.1016/0306-4522(95)00001-y" @default.
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• W2078153457 hasPublicationYear "1995" @default.
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