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• W2078154562 abstract "Objective: Polymorphisms that reduce the activity of reduced folate carrier (RFC) and methylenetetrahydrofolate reductase (MTHFR) and double (2R2R) or triple (3R3R) 28-bp tandem repeats in the promoter region of thymidylate synthase (TS) have been associated with the risk of childhood acute leukemia (AL). A case-control genotyping study was conducted in Brazilian children with the aim of investigating RFC, MTHFR, and TS polymorphisms as risk factors. Methods: The polymerase chain reaction-restriction fragment length polymorphism method was employed in 177 AL cases and 390 controls. Results: The presence of the mutant 1298C, also RFC 80A, was linked to a decreased risk of developing acute lymphoid leukemia (ALL) (odds ratio (OR)=0.46, 95% confidence interval (CI)=0.30–071 and OR=0.51, 95% CI=0.28–0.0.93, respectively). Conclusions: The genotype 677 CT was associated with increased risk of developing ALL (OR=1.6, 95% CI=1.1–2.7). Further epidemiological study is needed to unravel the role of complex multiple gene–environment interactions in leukemogenesis." @default.
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• W2078154562 date "2013-02-01" @default.
• W2078154562 modified "2023-09-27" @default.
• W2078154562 title "Polymorphisms Involved in Folate Metabolism Pathways and the Risk of the Development of Childhood Acute Leukemia" @default.
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• W2078154562 doi "https://doi.org/10.1089/gtmb.2012.0174" @default.
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