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• W2078155462 abstract "Abstract: Liver transplantation with liver grafts from deceased donors is the treatment of choice for patients suffering from Wilson's disease (WD) with end‐stage liver disease. There are few reports, however, on the use of liver grafts from living‐related donors for WD. Five (two pediatric and three adult recipients) underwent living‐related liver transplantation (LRLT) for WD at the University of Tokyo. Two patients presented with fulminant hepatic failure with hemolysis, and the other three presented with decompensating cirrhosis, one with an overlapping neurologic WD. All recipients had a low serum ceruloplasmin level (median: 18 mg/dL), high urinary copper level (mean: 1119 μ g/d), and presented with Kayser–Fleischer rings before transplantation. Although one patient died from early graft thrombosis unrelated to WD, the other four patients have shown an excellent long‐term prognosis. Following successful transplantation, there was a significant reduction in urinary copper excretion (median: 64 μ g/d) in all patients. The neurologic symptoms of WD in one patient, however, worsened after 2 months and gradually subsided, but not completely, over the 2‐yr follow‐up. For advanced liver failure in WD, we consider LRLT a valuable life‐saving option. The improvement of neurologic symptoms, however, requires further evaluation." @default.
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• W2078155462 date "2005-07-05" @default.
• W2078155462 modified "2023-10-11" @default.
• W2078155462 title "Living-related liver transplantation for Wilson's disease" @default.
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• W2078155462 doi "https://doi.org/10.1111/j.1399-0012.2005.00371.x" @default.
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