FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078157537> ?p ?o ?g. }

• W2078157537 endingPage "26816" @default.
• W2078157537 startingPage "26804" @default.
• W2078157537 abstract "Tumors are often greatly dependent on signaling cascades promoting cell growth or survival and may become hypersensitive to inactivation of key components within these signaling pathways. Ras and RAF mutations found in human cancer confer constitutive activity to these signaling molecules thereby converting them into an oncogenic state. RAF dimerization is required for normal Ras-dependent RAF activation and is required for the oncogenic potential of mutant RAFs. Here we describe a new mouse model for lung tumor development to investigate the role of B-RAF in oncogenic C-RAF-mediated adenoma initiation and growth. Conditional elimination of B-RAF in C-RAF BxB-expressing embryonic alveolar epithelial type II cells did not block adenoma formation. However, loss of B-RAF led to significantly reduced tumor growth. The diminished tumor growth upon B-RAF inactivation was due to reduced cell proliferation in absence of senescence and increased apoptosis. Furthermore, B-RAF elimination inhibited C-RAF BxB-mediated activation of the mitogenic cascade. In line with these data, mutation of Ser-621 in C-RAF BxB abrogated in vitro the dimerization with B-RAF and blocked the ability to activate the MAPK cascade. Taken together these data indicate that B-RAF is an important factor in oncogenic C-RAF-mediated tumorigenesis." @default.
• W2078157537 created "2016-06-24" @default.
• W2078157537 creator A5001270756 @default.
• W2078157537 creator A5016511599 @default.
• W2078157537 creator A5017393050 @default.
• W2078157537 creator A5019933637 @default.
• W2078157537 creator A5052761819 @default.
• W2078157537 creator A5057356110 @default.
• W2078157537 creator A5061019810 @default.
• W2078157537 creator A5090328045 @default.
• W2078157537 creator A5090499464 @default.
• W2078157537 date "2014-09-01" @default.
• W2078157537 modified "2023-10-18" @default.
• W2078157537 title "Elimination of B-RAF in Oncogenic C-RAF-expressing Alveolar Epithelial Type II Cells Reduces MAPK Signal Intensity and Lung Tumor Growth" @default.
• W2078157537 cites W1756746580 @default.
• W2078157537 cites W1977280665 @default.
• W2078157537 cites W2004295816 @default.
• W2078157537 cites W2013185521 @default.
• W2078157537 cites W2016467292 @default.
• W2078157537 cites W2025233368 @default.
• W2078157537 cites W2029575024 @default.
• W2078157537 cites W2030625725 @default.
• W2078157537 cites W2051165598 @default.
• W2078157537 cites W2067117191 @default.
• W2078157537 cites W2078334493 @default.
• W2078157537 cites W2097467678 @default.
• W2078157537 cites W2102646127 @default.
• W2078157537 cites W2110487056 @default.
• W2078157537 cites W2119403213 @default.
• W2078157537 cites W2123551753 @default.
• W2078157537 cites W2140765540 @default.
• W2078157537 cites W2144708319 @default.
• W2078157537 cites W2149662085 @default.
• W2078157537 cites W2163188200 @default.
• W2078157537 cites W2167197258 @default.
• W2078157537 cites W35957379 @default.
• W2078157537 doi "https://doi.org/10.1074/jbc.m114.558999" @default.
• W2078157537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4175323" @default.
• W2078157537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25096573" @default.
• W2078157537 hasPublicationYear "2014" @default.
• W2078157537 type Work @default.
• W2078157537 sameAs 2078157537 @default.
• W2078157537 citedByCount "7" @default.
• W2078157537 countsByYear W20781575372016 @default.
• W2078157537 countsByYear W20781575372017 @default.
• W2078157537 countsByYear W20781575372018 @default.
• W2078157537 countsByYear W20781575372020 @default.
• W2078157537 countsByYear W20781575372022 @default.
• W2078157537 crossrefType "journal-article" @default.
• W2078157537 hasAuthorship W2078157537A5001270756 @default.
• W2078157537 hasAuthorship W2078157537A5016511599 @default.
• W2078157537 hasAuthorship W2078157537A5017393050 @default.
• W2078157537 hasAuthorship W2078157537A5019933637 @default.
• W2078157537 hasAuthorship W2078157537A5052761819 @default.
• W2078157537 hasAuthorship W2078157537A5057356110 @default.
• W2078157537 hasAuthorship W2078157537A5061019810 @default.
• W2078157537 hasAuthorship W2078157537A5090328045 @default.
• W2078157537 hasAuthorship W2078157537A5090499464 @default.
• W2078157537 hasBestOaLocation W20781575371 @default.
• W2078157537 hasConcept C121608353 @default.
• W2078157537 hasConcept C153911025 @default.
• W2078157537 hasConcept C185592680 @default.
• W2078157537 hasConcept C502942594 @default.
• W2078157537 hasConcept C54355233 @default.
• W2078157537 hasConcept C55493867 @default.
• W2078157537 hasConcept C555283112 @default.
• W2078157537 hasConcept C57074206 @default.
• W2078157537 hasConcept C62112901 @default.
• W2078157537 hasConcept C62478195 @default.
• W2078157537 hasConcept C86803240 @default.
• W2078157537 hasConcept C95444343 @default.
• W2078157537 hasConceptScore W2078157537C121608353 @default.
• W2078157537 hasConceptScore W2078157537C153911025 @default.
• W2078157537 hasConceptScore W2078157537C185592680 @default.
• W2078157537 hasConceptScore W2078157537C502942594 @default.
• W2078157537 hasConceptScore W2078157537C54355233 @default.
• W2078157537 hasConceptScore W2078157537C55493867 @default.
• W2078157537 hasConceptScore W2078157537C555283112 @default.
• W2078157537 hasConceptScore W2078157537C57074206 @default.
• W2078157537 hasConceptScore W2078157537C62112901 @default.
• W2078157537 hasConceptScore W2078157537C62478195 @default.
• W2078157537 hasConceptScore W2078157537C86803240 @default.
• W2078157537 hasConceptScore W2078157537C95444343 @default.
• W2078157537 hasIssue "39" @default.
• W2078157537 hasLocation W20781575371 @default.
• W2078157537 hasLocation W20781575372 @default.
• W2078157537 hasLocation W20781575373 @default.
• W2078157537 hasLocation W20781575374 @default.
• W2078157537 hasOpenAccess W2078157537 @default.
• W2078157537 hasPrimaryLocation W20781575371 @default.
• W2078157537 hasRelatedWork W2020735591 @default.
• W2078157537 hasRelatedWork W2027244603 @default.
• W2078157537 hasRelatedWork W2066113694 @default.
• W2078157537 hasRelatedWork W2107269111 @default.
• W2078157537 hasRelatedWork W2381340599 @default.
• W2078157537 hasRelatedWork W2384817912 @default.
• W2078157537 hasRelatedWork W2462039273 @default.
• W2078157537 hasRelatedWork W2555005730 @default.

• next