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- W2078157569 abstract "Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease." @default.
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- W2078157569 date "2011-07-01" @default.
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- W2078157569 title "N-Acylhydrazones as inhibitors of PDE10A" @default.
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- W2078157569 doi "https://doi.org/10.1016/j.bmcl.2011.05.100" @default.
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