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- W2078160110 abstract "Background Osteopontin represents a multifunctional molecule playing a pivotal role in chronic inflammatory and autoimmune diseases. Its expression is increased in inflammatory bowel disease (IBD). The aim of our study was to analyze the association of osteopontin (OPN/SPP1) gene variants in a large cohort of IBD patients. Methodology/Principal Findings Genomic DNA from 2819 Caucasian individuals (n = 841 patients with Crohn's disease (CD), n = 473 patients with ulcerative colitis (UC), and n = 1505 healthy unrelated controls) was analyzed for nine OPN SNPs (rs2728127, rs2853744, rs11730582, rs11739060, rs28357094, rs4754 = p.Asp80Asp, rs1126616 = p.Ala236Ala, rs1126772 and rs9138). Considering the important role of osteopontin in Th17-mediated diseases, we performed analysis for epistasis with IBD-associated IL23R variants and analyzed serum levels of the Th17 cytokine IL-22. For four OPN SNPs (rs4754, rs1126616, rs1126772 and rs9138), we observed significantly different distributions between male and female CD patients. rs4754 was protective in male CD patients (p = 0.0004, OR = 0.69). None of the other investigated OPN SNPs was associated with CD or UC susceptibility. However, several OPN haplotypes showed significant associations with CD susceptibility. The strongest association was found for a haplotype consisting of the 8 OPN SNPs rs2728127-rs2853744-rs11730582-rs11439060-rs28357094-rs112661-rs1126772-rs9138 (omnibus p-value = 2.07×10−8). Overall, the mean IL-22 secretion in the combined group of OPN minor allele carriers with CD was significantly lower than that of CD patients with OPN wildtype alleles (p = 3.66×10−5). There was evidence for weak epistasis between the OPN SNP rs28357094 with the IL23R SNP rs10489629 (p = 4.18×10−2) and between OPN SNP rs1126616 and IL23R SNP rs2201841 (p = 4.18×10−2) but none of these associations remained significant after Bonferroni correction. Conclusions/Significance Our study identified OPN haplotypes as modifiers of CD susceptibility, while the combined effects of certain OPN variants may modulate IL-22 secretion." @default.
- W2078160110 created "2016-06-24" @default.
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- W2078160110 date "2011-12-29" @default.
- W2078160110 modified "2023-10-08" @default.
- W2078160110 title "The Role of Osteopontin (OPN/SPP1) Haplotypes in the Susceptibility to Crohn's Disease" @default.
- W2078160110 cites W1560102881 @default.
- W2078160110 cites W1584352251 @default.
- W2078160110 cites W1642457845 @default.
- W2078160110 cites W1670573097 @default.
- W2078160110 cites W1716523897 @default.
- W2078160110 cites W1964052073 @default.
- W2078160110 cites W1970044643 @default.
- W2078160110 cites W1973994873 @default.
- W2078160110 cites W1977283269 @default.
- W2078160110 cites W1978961215 @default.
- W2078160110 cites W1980725116 @default.
- W2078160110 cites W1981547878 @default.
- W2078160110 cites W1981714996 @default.
- W2078160110 cites W1987488978 @default.
- W2078160110 cites W1988060302 @default.
- W2078160110 cites W1989581181 @default.
- W2078160110 cites W1990526837 @default.
- W2078160110 cites W1991733645 @default.
- W2078160110 cites W2005553679 @default.
- W2078160110 cites W2008675789 @default.
- W2078160110 cites W2011163458 @default.
- W2078160110 cites W2011197968 @default.
- W2078160110 cites W2013972173 @default.
- W2078160110 cites W2017904488 @default.
- W2078160110 cites W2024233690 @default.
- W2078160110 cites W2024286402 @default.
- W2078160110 cites W2027560883 @default.
- W2078160110 cites W2028963532 @default.
- W2078160110 cites W2029239231 @default.
- W2078160110 cites W2029710444 @default.
- W2078160110 cites W2032375797 @default.
- W2078160110 cites W2035046681 @default.
- W2078160110 cites W2035325436 @default.
- W2078160110 cites W2042758849 @default.
- W2078160110 cites W2044198438 @default.
- W2078160110 cites W2044580027 @default.
- W2078160110 cites W2045181033 @default.
- W2078160110 cites W2052616002 @default.
- W2078160110 cites W2053624174 @default.
- W2078160110 cites W2057124042 @default.
- W2078160110 cites W2058520337 @default.
- W2078160110 cites W2070258812 @default.
- W2078160110 cites W2072582122 @default.
- W2078160110 cites W2075387167 @default.
- W2078160110 cites W2076518502 @default.
- W2078160110 cites W2084119784 @default.
- W2078160110 cites W2089794703 @default.
- W2078160110 cites W2091385024 @default.
- W2078160110 cites W2091705663 @default.
- W2078160110 cites W2096616042 @default.
- W2078160110 cites W2097087846 @default.
- W2078160110 cites W2104201959 @default.
- W2078160110 cites W2104806413 @default.
- W2078160110 cites W2106070528 @default.
- W2078160110 cites W2106779017 @default.
- W2078160110 cites W2107066107 @default.
- W2078160110 cites W2114560977 @default.
- W2078160110 cites W2117062936 @default.
- W2078160110 cites W2130179794 @default.
- W2078160110 cites W2139121810 @default.
- W2078160110 cites W2142480558 @default.
- W2078160110 cites W2148019512 @default.
- W2078160110 cites W2150724613 @default.
- W2078160110 cites W2151665160 @default.
- W2078160110 cites W2164699191 @default.
- W2078160110 cites W2165234873 @default.
- W2078160110 cites W2183219427 @default.
- W2078160110 cites W2188248802 @default.
- W2078160110 cites W4233255632 @default.
- W2078160110 cites W4312863584 @default.
- W2078160110 cites W45643372 @default.
- W2078160110 doi "https://doi.org/10.1371/journal.pone.0029309" @default.
- W2078160110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3248444" @default.
- W2078160110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22242114" @default.
- W2078160110 hasPublicationYear "2011" @default.
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