FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078160165> ?p ?o ?g. }

• W2078160165 endingPage "85" @default.
• W2078160165 startingPage "85" @default.
• W2078160165 abstract "The transcription factor Yin Yang 1 (YY1) is a ubiquitously expressed, multifunctional protein that controls a large number of genes and biological processes in vertebrates. As a general transcription factor, the proper levels of YY1 protein need to be maintained for the normal function of cells and organisms. However, the mechanism for the YY1 homeostasis is currently unknown.The current study reports that the YY1 gene locus of all vertebrates contains a cluster of its own DNA-binding sites within the 1st intron. The intact structure of these DNA-binding sites is absolutely necessary for transcriptional activity of the YY1 promoter. In an inducible cell line system that over-expresses an exogenous YY1 gene, the overall increased levels of YY1 protein caused a reduction in transcription levels of the endogenous YY1 gene. Reversion to the normal levels of YY1 protein restored the transcriptional levels of the endogenous YY1 to normal levels. This homeostatic response was also mediated through its cluster of YY1 binding sites.Taken together, the transcriptional level of YY1 is self-regulated through its internal DNA-binding sites. This study identifies YY1 as the first known autoregulating transcription factor in mammalian genomes." @default.
• W2078160165 created "2016-06-24" @default.
• W2078160165 creator A5044936635 @default.
• W2078160165 creator A5066322160 @default.
• W2078160165 creator A5086781241 @default.
• W2078160165 date "2009-01-01" @default.
• W2078160165 modified "2023-10-03" @default.
• W2078160165 title "YY1 is autoregulated through its own DNA-binding sites" @default.
• W2078160165 cites W1511355106 @default.
• W2078160165 cites W1855977133 @default.
• W2078160165 cites W1981101983 @default.
• W2078160165 cites W1983241347 @default.
• W2078160165 cites W1998580741 @default.
• W2078160165 cites W2008710304 @default.
• W2078160165 cites W2012277165 @default.
• W2078160165 cites W2018222564 @default.
• W2078160165 cites W2026290399 @default.
• W2078160165 cites W2044561872 @default.
• W2078160165 cites W2061425021 @default.
• W2078160165 cites W2075832020 @default.
• W2078160165 cites W2082496903 @default.
• W2078160165 cites W2113556902 @default.
• W2078160165 cites W2140600359 @default.
• W2078160165 cites W2146849272 @default.
• W2078160165 cites W2150712887 @default.
• W2078160165 cites W2157873533 @default.
• W2078160165 cites W2158301564 @default.
• W2078160165 cites W2267145511 @default.
• W2078160165 cites W597440835 @default.
• W2078160165 doi "https://doi.org/10.1186/1471-2199-10-85" @default.
• W2078160165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2743690" @default.
• W2078160165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19712462" @default.
• W2078160165 hasPublicationYear "2009" @default.
• W2078160165 type Work @default.
• W2078160165 sameAs 2078160165 @default.
• W2078160165 citedByCount "31" @default.
• W2078160165 countsByYear W20781601652013 @default.
• W2078160165 countsByYear W20781601652014 @default.
• W2078160165 countsByYear W20781601652015 @default.
• W2078160165 countsByYear W20781601652016 @default.
• W2078160165 countsByYear W20781601652017 @default.
• W2078160165 countsByYear W20781601652018 @default.
• W2078160165 countsByYear W20781601652019 @default.
• W2078160165 countsByYear W20781601652020 @default.
• W2078160165 countsByYear W20781601652021 @default.
• W2078160165 countsByYear W20781601652022 @default.
• W2078160165 countsByYear W20781601652023 @default.
• W2078160165 crossrefType "journal-article" @default.
• W2078160165 hasAuthorship W2078160165A5044936635 @default.
• W2078160165 hasAuthorship W2078160165A5066322160 @default.
• W2078160165 hasAuthorship W2078160165A5086781241 @default.
• W2078160165 hasBestOaLocation W20781601651 @default.
• W2078160165 hasConcept C101762097 @default.
• W2078160165 hasConcept C104317684 @default.
• W2078160165 hasConcept C138885662 @default.
• W2078160165 hasConcept C144825837 @default.
• W2078160165 hasConcept C150194340 @default.
• W2078160165 hasConcept C153911025 @default.
• W2078160165 hasConcept C165864922 @default.
• W2078160165 hasConcept C179926584 @default.
• W2078160165 hasConcept C27153228 @default.
• W2078160165 hasConcept C41895202 @default.
• W2078160165 hasConcept C54355233 @default.
• W2078160165 hasConcept C552990157 @default.
• W2078160165 hasConcept C62944979 @default.
• W2078160165 hasConcept C86339819 @default.
• W2078160165 hasConcept C86803240 @default.
• W2078160165 hasConcept C94966510 @default.
• W2078160165 hasConcept C95444343 @default.
• W2078160165 hasConceptScore W2078160165C101762097 @default.
• W2078160165 hasConceptScore W2078160165C104317684 @default.
• W2078160165 hasConceptScore W2078160165C138885662 @default.
• W2078160165 hasConceptScore W2078160165C144825837 @default.
• W2078160165 hasConceptScore W2078160165C150194340 @default.
• W2078160165 hasConceptScore W2078160165C153911025 @default.
• W2078160165 hasConceptScore W2078160165C165864922 @default.
• W2078160165 hasConceptScore W2078160165C179926584 @default.
• W2078160165 hasConceptScore W2078160165C27153228 @default.
• W2078160165 hasConceptScore W2078160165C41895202 @default.
• W2078160165 hasConceptScore W2078160165C54355233 @default.
• W2078160165 hasConceptScore W2078160165C552990157 @default.
• W2078160165 hasConceptScore W2078160165C62944979 @default.
• W2078160165 hasConceptScore W2078160165C86339819 @default.
• W2078160165 hasConceptScore W2078160165C86803240 @default.
• W2078160165 hasConceptScore W2078160165C94966510 @default.
• W2078160165 hasConceptScore W2078160165C95444343 @default.
• W2078160165 hasIssue "1" @default.
• W2078160165 hasLocation W20781601651 @default.
• W2078160165 hasLocation W20781601652 @default.
• W2078160165 hasLocation W20781601653 @default.
• W2078160165 hasLocation W20781601654 @default.
• W2078160165 hasLocation W20781601655 @default.
• W2078160165 hasOpenAccess W2078160165 @default.
• W2078160165 hasPrimaryLocation W20781601651 @default.
• W2078160165 hasRelatedWork W1870486696 @default.
• W2078160165 hasRelatedWork W1991812112 @default.
• W2078160165 hasRelatedWork W2020299722 @default.
• W2078160165 hasRelatedWork W2040437315 @default.

• next