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- W2078160716 abstract "Two ruthenium(II) complexes [Ru(bpy)2(bfipH)]2+ (1) and [Ru(phen)2(bfipH)]2+ (2) have been synthesized and characterized. The DNA-binding behaviors of complexes were studied by using spectroscopic and viscosity measurements. Results suggested that the two complexes bind to DNA in an intercalative mode. Complexes 1 and 2 can efficiently photocleave pBR322 DNA in vitro under irradiation, singlet oxygen (1O2) was proved to contribute to the DNA photocleavage process. Topoisomerase inhibition and DNA strand passage assay confirmed that two Ru(II) complexes acted as efficient dual inhibitors of topoisomerases I and II. In MTT cytotoxicity studies, two Ru(II) complexes exhibited antitumor activity against BEL-7402, HeLa, MCF-7 tumor cells. The AO/EB staining assay indicated that Ru(II) complexes could induce the apoptosis of HeLa cells." @default.
- W2078160716 created "2016-06-24" @default.
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- W2078160716 date "2011-04-01" @default.
- W2078160716 modified "2023-10-17" @default.
- W2078160716 title "Synthesis, DNA-binding and topoisomerase inhibitory activity of ruthenium(II) polypyridyl complexes" @default.
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- W2078160716 doi "https://doi.org/10.1016/j.ejmech.2011.01.019" @default.
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