Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078160883> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2078160883 endingPage "109" @default.
- W2078160883 startingPage "103" @default.
- W2078160883 abstract "Serological markers of cell-mediated immunity, i.e., soluble CD4, soluble interleukin-2 (Il-2) receptor and beta 2-microglobulin, were determined in 60 patients with dilated cardiomyopathy. Compared with normal healthy donors (n = 30) and controls who had coronary artery disease with preserved left ventricular function (n = 20), significantly increased levels associated with the New York Heart Association functional classes have been found in the cardiomyopathy patients, irrespectively of the etiology. Out of the immunological variables tested, serum-soluble CD4 most closely reflected the clinical and hemodynamic stage, predicted the presence of lymphocytic aggregates in the myocardium and correlated with the CD4/CD8 ratios of endomyocardial lymphocytes (r = 0.6, P < 0.05). Conversely, focal mononuclear infiltration of the myocardium was associated with significantly elevated CD4/CD8 ratios (2.1 +/- 0.6 vs. 1.3 +/- 0.2, P < 0.05), higher total numbers and percentages of endomyocardial lymphocytes expressing the pan T-markers CD2 and CD3, more CD45RO/UCHL1-positive cells and more CD4-positive T-helper cells, compared with non-reactive cases the lymphocytes of which were scattered throughout the myocardium. In conclusion, in a subset of cardiomyopathy patients lymphocytic clusters in the myocardium indicated an enhanced cellular immune response predominantly mediated by CD4-positive T-helper lymphocytes with active memory function. This immunopathological condition in the heart can be monitored by serum-soluble CD4." @default.
- W2078160883 created "2016-06-24" @default.
- W2078160883 creator A5006547876 @default.
- W2078160883 creator A5018882069 @default.
- W2078160883 creator A5020886257 @default.
- W2078160883 creator A5022504348 @default.
- W2078160883 creator A5025101440 @default.
- W2078160883 creator A5031972074 @default.
- W2078160883 creator A5049183081 @default.
- W2078160883 creator A5063351458 @default.
- W2078160883 creator A5064989558 @default.
- W2078160883 creator A5071435826 @default.
- W2078160883 creator A5078671884 @default.
- W2078160883 creator A5079149738 @default.
- W2078160883 date "1993-10-01" @default.
- W2078160883 modified "2023-10-16" @default.
- W2078160883 title "Serum-soluble CD4 as clinical and immunological marker in patients with dilated cardiomyopathy" @default.
- W2078160883 cites W1984281014 @default.
- W2078160883 cites W1993492475 @default.
- W2078160883 cites W1998849734 @default.
- W2078160883 cites W2010363665 @default.
- W2078160883 cites W2017003813 @default.
- W2078160883 cites W2020589313 @default.
- W2078160883 cites W2029014996 @default.
- W2078160883 cites W2035395868 @default.
- W2078160883 cites W2041267328 @default.
- W2078160883 cites W2051785701 @default.
- W2078160883 cites W2060872441 @default.
- W2078160883 cites W2071162998 @default.
- W2078160883 cites W2083851363 @default.
- W2078160883 cites W2085568008 @default.
- W2078160883 cites W2108614142 @default.
- W2078160883 cites W2122340151 @default.
- W2078160883 cites W2145258710 @default.
- W2078160883 cites W2260229005 @default.
- W2078160883 cites W2324476825 @default.
- W2078160883 doi "https://doi.org/10.1016/0165-2478(93)90174-z" @default.
- W2078160883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8294137" @default.
- W2078160883 hasPublicationYear "1993" @default.
- W2078160883 type Work @default.
- W2078160883 sameAs 2078160883 @default.
- W2078160883 citedByCount "6" @default.
- W2078160883 crossrefType "journal-article" @default.
- W2078160883 hasAuthorship W2078160883A5006547876 @default.
- W2078160883 hasAuthorship W2078160883A5018882069 @default.
- W2078160883 hasAuthorship W2078160883A5020886257 @default.
- W2078160883 hasAuthorship W2078160883A5022504348 @default.
- W2078160883 hasAuthorship W2078160883A5025101440 @default.
- W2078160883 hasAuthorship W2078160883A5031972074 @default.
- W2078160883 hasAuthorship W2078160883A5049183081 @default.
- W2078160883 hasAuthorship W2078160883A5063351458 @default.
- W2078160883 hasAuthorship W2078160883A5064989558 @default.
- W2078160883 hasAuthorship W2078160883A5071435826 @default.
- W2078160883 hasAuthorship W2078160883A5078671884 @default.
- W2078160883 hasAuthorship W2078160883A5079149738 @default.
- W2078160883 hasConcept C114684123 @default.
- W2078160883 hasConcept C126322002 @default.
- W2078160883 hasConcept C167672396 @default.
- W2078160883 hasConcept C203014093 @default.
- W2078160883 hasConcept C2776383484 @default.
- W2078160883 hasConcept C2778198053 @default.
- W2078160883 hasConcept C2778797674 @default.
- W2078160883 hasConcept C2780875844 @default.
- W2078160883 hasConcept C71924100 @default.
- W2078160883 hasConcept C8891405 @default.
- W2078160883 hasConceptScore W2078160883C114684123 @default.
- W2078160883 hasConceptScore W2078160883C126322002 @default.
- W2078160883 hasConceptScore W2078160883C167672396 @default.
- W2078160883 hasConceptScore W2078160883C203014093 @default.
- W2078160883 hasConceptScore W2078160883C2776383484 @default.
- W2078160883 hasConceptScore W2078160883C2778198053 @default.
- W2078160883 hasConceptScore W2078160883C2778797674 @default.
- W2078160883 hasConceptScore W2078160883C2780875844 @default.
- W2078160883 hasConceptScore W2078160883C71924100 @default.
- W2078160883 hasConceptScore W2078160883C8891405 @default.
- W2078160883 hasIssue "2" @default.
- W2078160883 hasLocation W20781608831 @default.
- W2078160883 hasLocation W20781608832 @default.
- W2078160883 hasOpenAccess W2078160883 @default.
- W2078160883 hasPrimaryLocation W20781608831 @default.
- W2078160883 hasRelatedWork W1977431078 @default.
- W2078160883 hasRelatedWork W1989894675 @default.
- W2078160883 hasRelatedWork W2034448651 @default.
- W2078160883 hasRelatedWork W2315824881 @default.
- W2078160883 hasRelatedWork W2397054411 @default.
- W2078160883 hasRelatedWork W2402738988 @default.
- W2078160883 hasRelatedWork W2410456140 @default.
- W2078160883 hasRelatedWork W2789718426 @default.
- W2078160883 hasRelatedWork W2988345283 @default.
- W2078160883 hasRelatedWork W4214863323 @default.
- W2078160883 hasVolume "38" @default.
- W2078160883 isParatext "false" @default.
- W2078160883 isRetracted "false" @default.
- W2078160883 magId "2078160883" @default.
- W2078160883 workType "article" @default.