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• W2078161164 abstract "The influcence of 21 kinds of components of plant essence on sister-chromatid exchanges (SCEs) induced by mitomycin C was investigated in cultured Chinese hamster CHO K-1 cells. Posttreatment with scopoletin, jasmone, caffeic acid and ferulic acid significantly increased the frequency of SCEs. Further investigation of the SCE-enhancing effect of analogues of caffeic acid and ferulic acid revealed that an α,β-unsaturated carbonyl group may be necessary for SCE-enhancing effects. The influence of caffeic acid and ferulic acid on X-ray- or UV-induced SCEs was also studied. The frequencies of SCEs induced by UV were increased by treatment with these compounds. This increasing effect was observed in the S phase of the cell cycle. On the contrary, X-ray-induced SCEs were reduced by the treatment with these compounds. The decreasing effect was observed in the G1 phase but not in the S or G2 phase. To explain these contradictory results, we assumed that caffeic acid and ferulic acid may modify the repair of DNA strand breaks." @default.
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• W2078161164 date "1989-06-01" @default.
• W2078161164 modified "2023-10-15" @default.
• W2078161164 title "Modifying effects of components of plant essence of the induction of sister-chromatid exchanges in cultured Chinese hamster ovary cells" @default.
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• W2078161164 doi "https://doi.org/10.1016/0165-7992(89)90051-1" @default.
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