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• W2078161232 endingPage "e1000013" @default.
• W2078161232 startingPage "e1000013" @default.
• W2078161232 abstract "The transcription factor Myc plays a central role in regulating cell-fate decisions, including proliferation, growth, and apoptosis. To maintain a normal cell physiology, it is critical that the control of Myc dynamics is precisely orchestrated. Recent studies suggest that such control of Myc can be achieved at the post-translational level via protein stability modulation. Myc is regulated by two Ras effector pathways: the extracellular signal-regulated kinase (Erk) and phosphatidylinositol 3-kinase (PI3K) pathways. To gain quantitative insight into Myc dynamics, we have developed a mathematical model to analyze post-translational regulation of Myc via sequential phosphorylation by Erk and PI3K. Our results suggest that Myc integrates Erk and PI3K signals to result in various cellular responses by differential stability control of Myc protein isoforms. Such signal integration confers a flexible dynamic range for the system output, governed by stability change. In addition, signal integration may require saturation of the input signals, leading to sensitive signal integration to the temporal features of the input signals, insensitive response to their amplitudes, and resistance to input fluctuations. We further propose that these characteristics of the protein stability control module in Myc may be commonly utilized in various cell types and classes of proteins." @default.
• W2078161232 created "2016-06-24" @default.
• W2078161232 creator A5016251947 @default.
• W2078161232 creator A5041753886 @default.
• W2078161232 creator A5052547773 @default.
• W2078161232 creator A5081481623 @default.
• W2078161232 date "2008-02-29" @default.
• W2078161232 modified "2023-10-18" @default.
• W2078161232 title "Sensing and Integration of Erk and PI3K Signals by Myc" @default.
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• W2078161232 cites W1973633445 @default.
• W2078161232 cites W1976558883 @default.
• W2078161232 cites W1976874039 @default.
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• W2078161232 doi "https://doi.org/10.1371/journal.pcbi.1000013" @default.
• W2078161232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2265471" @default.
• W2078161232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18463697" @default.
• W2078161232 hasPublicationYear "2008" @default.
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