FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078162613> ?p ?o ?g. }

• W2078162613 endingPage "7101" @default.
• W2078162613 startingPage "7094" @default.
• W2078162613 abstract "Experiments were conducted to investigate the effect of a fusion gene of porcine IL-4 and IL-6 (PIL4/IL6) packaged with chitosan nanoparticles (CNPs) in terms of the development of a novel effective adjuvant. The IL4/PIL6 fusion gene was constructed and inserted into a eukaryotic expression vector. The plasmid was bound to CNP and then utilized to orally inoculate 21-day-old female Kunming mice that simultaneously received intramuscular injection of inactivated Escherichia coli vaccine. At 35 days post-vaccination, the mice were challenged by oral feeding with virulent O139: K88 strain EPEC E. coli bacteria. Compared with those of control mice, the content of immunoglobulins and specific antibodies to E. coli increased significantly in the sera of mice immunized with VPIL4/IL6-CNP (P < 0.05). Furthermore, the levels of IL-2, IL-4 and IL-6 increased remarkably in the sera of immunized mice (P < 0.05). After challenge, these immunological markers were elevated to different degrees in the mice immunized with the fusion gene construct (IL4/VPIL6–CNP) or individual plasmids (VPIL4 + VPIL6–CNP). The immunized mice all survived the challenge and did not show any symptoms or lesion, whereas the VR1020-CNP control mice manifested obvious clinical symptoms and hemorrhagic lesions in the digestive tracts. These results demonstrated that VPIL4/IL6 entrapped with CNP is a novel promising adjuvant to promote specific immunity and resistance of animals against infectious pathogen." @default.
• W2078162613 created "2016-06-24" @default.
• W2078162613 creator A5008364949 @default.
• W2078162613 creator A5016439888 @default.
• W2078162613 creator A5020657719 @default.
• W2078162613 creator A5024120345 @default.
• W2078162613 creator A5026302891 @default.
• W2078162613 creator A5026472376 @default.
• W2078162613 creator A5028197455 @default.
• W2078162613 creator A5035557906 @default.
• W2078162613 creator A5050529072 @default.
• W2078162613 creator A5052135528 @default.
• W2078162613 creator A5060888542 @default.
• W2078162613 creator A5078965986 @default.
• W2078162613 creator A5081826033 @default.
• W2078162613 creator A5085094109 @default.
• W2078162613 date "2007-10-01" @default.
• W2078162613 modified "2023-10-17" @default.
• W2078162613 title "Enhancement of immunity to an Escherichia coli vaccine in mice orally inoculated with a fusion gene encoding porcine interleukin 4 and 6" @default.
• W2078162613 cites W1511118087 @default.
• W2078162613 cites W1536718135 @default.
• W2078162613 cites W1586799259 @default.
• W2078162613 cites W1590437543 @default.
• W2078162613 cites W1978643345 @default.
• W2078162613 cites W1994778927 @default.
• W2078162613 cites W2004279505 @default.
• W2078162613 cites W2007807506 @default.
• W2078162613 cites W2021313773 @default.
• W2078162613 cites W2033351973 @default.
• W2078162613 cites W2043904554 @default.
• W2078162613 cites W2045149506 @default.
• W2078162613 cites W2048039934 @default.
• W2078162613 cites W2053611023 @default.
• W2078162613 cites W2054427090 @default.
• W2078162613 cites W2058353222 @default.
• W2078162613 cites W2066993659 @default.
• W2078162613 cites W2067312720 @default.
• W2078162613 cites W2086935843 @default.
• W2078162613 cites W2102482614 @default.
• W2078162613 cites W2112111992 @default.
• W2078162613 cites W2148993123 @default.
• W2078162613 cites W2317410864 @default.
• W2078162613 cites W29247090 @default.
• W2078162613 doi "https://doi.org/10.1016/j.vaccine.2007.07.050" @default.
• W2078162613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17868957" @default.
• W2078162613 hasPublicationYear "2007" @default.
• W2078162613 type Work @default.
• W2078162613 sameAs 2078162613 @default.
• W2078162613 citedByCount "28" @default.
• W2078162613 countsByYear W20781626132012 @default.
• W2078162613 countsByYear W20781626132013 @default.
• W2078162613 countsByYear W20781626132014 @default.
• W2078162613 countsByYear W20781626132015 @default.
• W2078162613 countsByYear W20781626132017 @default.
• W2078162613 countsByYear W20781626132018 @default.
• W2078162613 countsByYear W20781626132019 @default.
• W2078162613 countsByYear W20781626132020 @default.
• W2078162613 countsByYear W20781626132022 @default.
• W2078162613 crossrefType "journal-article" @default.
• W2078162613 hasAuthorship W2078162613A5008364949 @default.
• W2078162613 hasAuthorship W2078162613A5016439888 @default.
• W2078162613 hasAuthorship W2078162613A5020657719 @default.
• W2078162613 hasAuthorship W2078162613A5024120345 @default.
• W2078162613 hasAuthorship W2078162613A5026302891 @default.
• W2078162613 hasAuthorship W2078162613A5026472376 @default.
• W2078162613 hasAuthorship W2078162613A5028197455 @default.
• W2078162613 hasAuthorship W2078162613A5035557906 @default.
• W2078162613 hasAuthorship W2078162613A5050529072 @default.
• W2078162613 hasAuthorship W2078162613A5052135528 @default.
• W2078162613 hasAuthorship W2078162613A5060888542 @default.
• W2078162613 hasAuthorship W2078162613A5078965986 @default.
• W2078162613 hasAuthorship W2078162613A5081826033 @default.
• W2078162613 hasAuthorship W2078162613A5085094109 @default.
• W2078162613 hasConcept C104317684 @default.
• W2078162613 hasConcept C123894998 @default.
• W2078162613 hasConcept C159047783 @default.
• W2078162613 hasConcept C159654299 @default.
• W2078162613 hasConcept C203014093 @default.
• W2078162613 hasConcept C22070199 @default.
• W2078162613 hasConcept C22744801 @default.
• W2078162613 hasConcept C2776460866 @default.
• W2078162613 hasConcept C2777863537 @default.
• W2078162613 hasConcept C2779341262 @default.
• W2078162613 hasConcept C40767141 @default.
• W2078162613 hasConcept C547475151 @default.
• W2078162613 hasConcept C55493867 @default.
• W2078162613 hasConcept C60987743 @default.
• W2078162613 hasConcept C86803240 @default.
• W2078162613 hasConcept C8891405 @default.
• W2078162613 hasConcept C89423630 @default.
• W2078162613 hasConceptScore W2078162613C104317684 @default.
• W2078162613 hasConceptScore W2078162613C123894998 @default.
• W2078162613 hasConceptScore W2078162613C159047783 @default.
• W2078162613 hasConceptScore W2078162613C159654299 @default.
• W2078162613 hasConceptScore W2078162613C203014093 @default.
• W2078162613 hasConceptScore W2078162613C22070199 @default.
• W2078162613 hasConceptScore W2078162613C22744801 @default.
• W2078162613 hasConceptScore W2078162613C2776460866 @default.

• next