FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078162856> ?p ?o ?g. }

• W2078162856 endingPage "53" @default.
• W2078162856 startingPage "48" @default.
• W2078162856 abstract "Arsenic (+3 oxidation state) methyltransferase (As3MT) catalyzes the methylation of trivalent arsenic (As(III)) to monomethylarsonate (MMA(V)) and dimethylarsinic acid (DMA(V)), and plays an important role in the detoxification of arsenicals. Here, we report the identification of two splicing variants of the human As3MT gene. One splicing variant was an exon-3 skipping (Δ3) form which produced a premature stop codon, and the other was an exon-4 and -5 skipping (Δ4,5) form which produced a 31.1 kDa As3MT protein. In addition to the full-length mRNA of As3MT, Δ4,5 mRNAs were detected in HepG2, A549, HL60, K562, and HEK293 cells. The methyltransferase activity of the recombinant Δ4,5 As3MT and wild-type As3MT proteins purified from Escherichia coli was determined. Speciation analysis by HPLC-ICP-MS showed a clear peak of MMA(V) after incubation of As(III) with the wild-type As3MT protein, but not with the Δ4,5 As3MT protein. In addition, COS-7 cells transfected with Δ4,5 As3MT cDNA did not convert As(III) to MMA(V) or DMA(V). The lack of methyltransferase activity of Δ4,5 As3MT seems to be related to the deletion of an S-adenosylmethionine-binding site and a critical cysteine residue. These data suggest that the expression pattern of splicing variants of the As3MT gene may affect the capacity for arsenic methylation in cells." @default.
• W2078162856 created "2016-06-24" @default.
• W2078162856 creator A5011171466 @default.
• W2078162856 creator A5012037110 @default.
• W2078162856 creator A5032009727 @default.
• W2078162856 creator A5069574183 @default.
• W2078162856 date "2011-11-01" @default.
• W2078162856 modified "2023-10-10" @default.
• W2078162856 title "Alternative splicing variants of human arsenic (+3 oxidation state) methyltransferase" @default.
• W2078162856 cites W1777939053 @default.
• W2078162856 cites W1982906604 @default.
• W2078162856 cites W1983109180 @default.
• W2078162856 cites W1986077139 @default.
• W2078162856 cites W1999075349 @default.
• W2078162856 cites W1999948851 @default.
• W2078162856 cites W2003021208 @default.
• W2078162856 cites W2003605043 @default.
• W2078162856 cites W2007347986 @default.
• W2078162856 cites W2007395768 @default.
• W2078162856 cites W2011920499 @default.
• W2078162856 cites W2017370342 @default.
• W2078162856 cites W2028333449 @default.
• W2078162856 cites W2031170601 @default.
• W2078162856 cites W2034167398 @default.
• W2078162856 cites W2035010751 @default.
• W2078162856 cites W2040456000 @default.
• W2078162856 cites W2040780606 @default.
• W2078162856 cites W2045978319 @default.
• W2078162856 cites W2047773767 @default.
• W2078162856 cites W2047975812 @default.
• W2078162856 cites W2050086208 @default.
• W2078162856 cites W2062178929 @default.
• W2078162856 cites W2065170814 @default.
• W2078162856 cites W2065710776 @default.
• W2078162856 cites W2080430831 @default.
• W2078162856 cites W2085033409 @default.
• W2078162856 cites W2086201153 @default.
• W2078162856 cites W2096876385 @default.
• W2078162856 cites W2097957264 @default.
• W2078162856 cites W2109936378 @default.
• W2078162856 cites W2155804510 @default.
• W2078162856 cites W2157936723 @default.
• W2078162856 cites W2228722601 @default.
• W2078162856 cites W2314037093 @default.
• W2078162856 doi "https://doi.org/10.1016/j.bbrc.2011.10.008" @default.
• W2078162856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22005461" @default.
• W2078162856 hasPublicationYear "2011" @default.
• W2078162856 type Work @default.
• W2078162856 sameAs 2078162856 @default.
• W2078162856 citedByCount "11" @default.
• W2078162856 countsByYear W20781628562013 @default.
• W2078162856 countsByYear W20781628562014 @default.
• W2078162856 countsByYear W20781628562015 @default.
• W2078162856 countsByYear W20781628562016 @default.
• W2078162856 countsByYear W20781628562018 @default.
• W2078162856 countsByYear W20781628562019 @default.
• W2078162856 countsByYear W20781628562020 @default.
• W2078162856 countsByYear W20781628562021 @default.
• W2078162856 crossrefType "journal-article" @default.
• W2078162856 hasAuthorship W2078162856A5011171466 @default.
• W2078162856 hasAuthorship W2078162856A5012037110 @default.
• W2078162856 hasAuthorship W2078162856A5032009727 @default.
• W2078162856 hasAuthorship W2078162856A5069574183 @default.
• W2078162856 hasConcept C104317684 @default.
• W2078162856 hasConcept C153911025 @default.
• W2078162856 hasConcept C185592680 @default.
• W2078162856 hasConcept C194583182 @default.
• W2078162856 hasConcept C33288867 @default.
• W2078162856 hasConcept C36823959 @default.
• W2078162856 hasConcept C54458228 @default.
• W2078162856 hasConcept C55493867 @default.
• W2078162856 hasConcept C67705224 @default.
• W2078162856 hasConcept C86803240 @default.
• W2078162856 hasConcept C91965660 @default.
• W2078162856 hasConceptScore W2078162856C104317684 @default.
• W2078162856 hasConceptScore W2078162856C153911025 @default.
• W2078162856 hasConceptScore W2078162856C185592680 @default.
• W2078162856 hasConceptScore W2078162856C194583182 @default.
• W2078162856 hasConceptScore W2078162856C33288867 @default.
• W2078162856 hasConceptScore W2078162856C36823959 @default.
• W2078162856 hasConceptScore W2078162856C54458228 @default.
• W2078162856 hasConceptScore W2078162856C55493867 @default.
• W2078162856 hasConceptScore W2078162856C67705224 @default.
• W2078162856 hasConceptScore W2078162856C86803240 @default.
• W2078162856 hasConceptScore W2078162856C91965660 @default.
• W2078162856 hasIssue "1" @default.
• W2078162856 hasLocation W20781628561 @default.
• W2078162856 hasLocation W20781628562 @default.
• W2078162856 hasOpenAccess W2078162856 @default.
• W2078162856 hasPrimaryLocation W20781628561 @default.
• W2078162856 hasRelatedWork W178291922 @default.
• W2078162856 hasRelatedWork W2003083382 @default.
• W2078162856 hasRelatedWork W2089104969 @default.
• W2078162856 hasRelatedWork W2130439870 @default.
• W2078162856 hasRelatedWork W2147652847 @default.
• W2078162856 hasRelatedWork W2151954452 @default.
• W2078162856 hasRelatedWork W2800537687 @default.
• W2078162856 hasRelatedWork W3147900171 @default.

• next