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- W2078163068 abstract "A growing body of evidence suggests that exercise enhances hippocampal plasticity and function through BDNF up-regulation, which is potentiated by antidepressant treatment. However, little is known about the molecular mechanisms mediating the effect of exercise. The present study investigated the effect of treadmill exercise on PI3K/Akt signaling, which mediates synaptic plasticity in the hippocampus of stressed rats. Rats were subjected to immobilization stress 2h/day for 7 days. The rats were run on the treadmill at a speed of 15m/min, 30min/day, for 5 days. Western blotting was used to assess changes in the levels of phospho-tyr(490)-Trk receptor, phospho-ser(473)-Akt, phospho-ser(9)-GSK-3β, phospho-ser(2448)- mTOR, and phosphor-thr(389)-p70S6K, and in BDNF and various synaptic proteins. Immobilization stress significantly decreased BDNF expression and phosphorylation of Trk receptor, Akt, GSK-3β, mTOR, and p70S6K in the hippocampus of rats; furthermore, synaptophysin, PSD-95, neuroligin 1, and β-neurexin were decreased. Treadmill exercise significantly attenuated the decreased expression of these proteins. Moreover, exercise significantly increased PI3K/Akt signaling in the absence of immobilization stress. These results suggest that treadmill exercise reverses stress-induced changes in the rat hippocampus via an increase in PI3K/Akt signaling and may induce a functional reconnection of hippocampal synapses that mediate antidepressant actions." @default.
- W2078163068 created "2016-06-24" @default.
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- W2078163068 date "2013-08-01" @default.
- W2078163068 modified "2023-10-14" @default.
- W2078163068 title "Effect of treadmill exercise on the BDNF-mediated pathway in the hippocampus of stressed rats" @default.
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- W2078163068 doi "https://doi.org/10.1016/j.neures.2013.04.005" @default.
- W2078163068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23665137" @default.
- W2078163068 hasPublicationYear "2013" @default.
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