Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078163698> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2078163698 endingPage "31" @default.
- W2078163698 startingPage "27" @default.
- W2078163698 abstract "Objective: To evaluate the influences of blood viscosity changes, mediated by a haemorheological agent, on splanchnic and systemic haemodynamic parameters in rats with cirrhosis due to chronic bile duct ligation. Methods: Blood viscosity was measured using a cone-plate viscometer and whole blood filterability was determined by a filtration method. Cardiac index and portal venous inflow were measured using radioactive microspheres. Measurements were performed 30min after double-blind administration of placebo or pentoxifylline (25 mg/kg, intravenously). Results: As compared with placebo, pentoxifylline-treated cirrhotic rats had a lower portal pressure (13.8±1.4 vs. 12.1 ± 1.6mmHg, P<0.05) and blood viscosity at shear rates of 115/s (6.6±0.8 vs. 5.8±0.3mPas, P<0.05), associated with an improvement of whole blood filterability (45.0±12.9 vs. 20.0±3.9s/ml, P <0.01). Similar values of mean arterial pressure, cardiac index and portal venous inflow were observed in both groups. A significant correlation was found between portal pressure and blood viscosity at a shear rate of 115/s (r=0.71, P<0.01). Conclusion: These results suggest that portal pressure can be modified by pentoxifylline in an experimental model of cirrhosis. These haemodynamic changes are associated with a lower blood viscosity and whole blood filterability. Pentoxifylline may be a new approach in the treatment of portal hypertension." @default.
- W2078163698 created "2016-06-24" @default.
- W2078163698 creator A5004859689 @default.
- W2078163698 creator A5057156920 @default.
- W2078163698 creator A5057357780 @default.
- W2078163698 creator A5081385973 @default.
- W2078163698 creator A5085049039 @default.
- W2078163698 date "1997-01-01" @default.
- W2078163698 modified "2023-10-16" @default.
- W2078163698 title "Pentoxifylline, a drug with rheological effects, decreases portal pressure in an experimental model of cirrhosis" @default.
- W2078163698 doi "https://doi.org/10.1097/00042737-199701000-00009" @default.
- W2078163698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9031895" @default.
- W2078163698 hasPublicationYear "1997" @default.
- W2078163698 type Work @default.
- W2078163698 sameAs 2078163698 @default.
- W2078163698 citedByCount "16" @default.
- W2078163698 countsByYear W20781636982014 @default.
- W2078163698 countsByYear W20781636982023 @default.
- W2078163698 crossrefType "journal-article" @default.
- W2078163698 hasAuthorship W2078163698A5004859689 @default.
- W2078163698 hasAuthorship W2078163698A5057156920 @default.
- W2078163698 hasAuthorship W2078163698A5057357780 @default.
- W2078163698 hasAuthorship W2078163698A5081385973 @default.
- W2078163698 hasAuthorship W2078163698A5085049039 @default.
- W2078163698 hasConcept C126322002 @default.
- W2078163698 hasConcept C158846371 @default.
- W2078163698 hasConcept C164705383 @default.
- W2078163698 hasConcept C178853913 @default.
- W2078163698 hasConcept C2777214474 @default.
- W2078163698 hasConcept C2777953023 @default.
- W2078163698 hasConcept C2778808290 @default.
- W2078163698 hasConcept C2780404050 @default.
- W2078163698 hasConcept C2780959883 @default.
- W2078163698 hasConcept C2992203999 @default.
- W2078163698 hasConcept C2994203641 @default.
- W2078163698 hasConcept C42219234 @default.
- W2078163698 hasConcept C56900294 @default.
- W2078163698 hasConcept C71924100 @default.
- W2078163698 hasConcept C84393581 @default.
- W2078163698 hasConceptScore W2078163698C126322002 @default.
- W2078163698 hasConceptScore W2078163698C158846371 @default.
- W2078163698 hasConceptScore W2078163698C164705383 @default.
- W2078163698 hasConceptScore W2078163698C178853913 @default.
- W2078163698 hasConceptScore W2078163698C2777214474 @default.
- W2078163698 hasConceptScore W2078163698C2777953023 @default.
- W2078163698 hasConceptScore W2078163698C2778808290 @default.
- W2078163698 hasConceptScore W2078163698C2780404050 @default.
- W2078163698 hasConceptScore W2078163698C2780959883 @default.
- W2078163698 hasConceptScore W2078163698C2992203999 @default.
- W2078163698 hasConceptScore W2078163698C2994203641 @default.
- W2078163698 hasConceptScore W2078163698C42219234 @default.
- W2078163698 hasConceptScore W2078163698C56900294 @default.
- W2078163698 hasConceptScore W2078163698C71924100 @default.
- W2078163698 hasConceptScore W2078163698C84393581 @default.
- W2078163698 hasIssue "1" @default.
- W2078163698 hasLocation W20781636981 @default.
- W2078163698 hasLocation W20781636982 @default.
- W2078163698 hasOpenAccess W2078163698 @default.
- W2078163698 hasPrimaryLocation W20781636981 @default.
- W2078163698 hasRelatedWork W1484938858 @default.
- W2078163698 hasRelatedWork W1911082026 @default.
- W2078163698 hasRelatedWork W2042485961 @default.
- W2078163698 hasRelatedWork W2075592854 @default.
- W2078163698 hasRelatedWork W2103915008 @default.
- W2078163698 hasRelatedWork W2168442414 @default.
- W2078163698 hasRelatedWork W2183535056 @default.
- W2078163698 hasRelatedWork W3145896936 @default.
- W2078163698 hasRelatedWork W4231088331 @default.
- W2078163698 hasRelatedWork W4307649185 @default.
- W2078163698 hasVolume "9" @default.
- W2078163698 isParatext "false" @default.
- W2078163698 isRetracted "false" @default.
- W2078163698 magId "2078163698" @default.
- W2078163698 workType "article" @default.