FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078164585> ?p ?o ?g. }

• W2078164585 endingPage "239" @default.
• W2078164585 startingPage "235" @default.
• W2078164585 abstract "The present study sought to verify effects of 5-HT on synaptic density at the ultrastructural level, to determine whether the 5-HT1a receptor is important for the maintenance of synaptic connections and to obtain evidence implicating S100β in the apparent neurotrophic actions of 5-HT. Reduction of hippocampal 5-HT with para-chloroamphetamine (PCA) resulted in a significant decline in the synaptic density of the dentate molecular layer. Reduction of norepinephrine with DSP-4 produced a slight decrease in the number of molecular layer synapses, but this difference was not statistically different from control values. 5-HT1a antagonist treatment resulted in a decline in synaptic density comparable to that observed following PCA treatment. These observations suggest that 5-HT functions to maintain synaptic connections in the dentate molecular layer via a 5-HT1a mechanism. To determine whether the change in synaptic density was due to the action of 5-HT on neuronal receptors or astrocytic receptors, a monoclonal antibody against S100β was infused into the lateral ventricle for seven days. Controls received infusions of normal goat serum. Half of the rats from the anti-S100β and control groups also received daily injections of NAN-190. Anti-S100β infusion resulted in a significant (p<0.01) decrease in synapses compared to serum controls. Concomitant NAN-190 administration did not enhance synapse loss in the anti-S100β group. The results of this study suggest that the maintenance of synaptic connections in the dentate molecular layer is influenced by S100β levels that are controlled by 5-HT stimulation of astrocytic 5-HT1a receptors." @default.
• W2078164585 created "2016-06-24" @default.
• W2078164585 creator A5028308111 @default.
• W2078164585 creator A5064679086 @default.
• W2078164585 creator A5065608007 @default.
• W2078164585 date "1998-01-01" @default.
• W2078164585 modified "2023-09-29" @default.
• W2078164585 title "Serotonin regulates synaptic connections in the dentate molecular layer of adult rats via 5-HT1a receptors: evidence for a glial mechanism" @default.
• W2078164585 cites W13021096 @default.
• W2078164585 cites W1897632924 @default.
• W2078164585 cites W1977170192 @default.
• W2078164585 cites W1979087509 @default.
• W2078164585 cites W1986673268 @default.
• W2078164585 cites W1989918737 @default.
• W2078164585 cites W1993538553 @default.
• W2078164585 cites W1994752284 @default.
• W2078164585 cites W2000056249 @default.
• W2078164585 cites W2001257014 @default.
• W2078164585 cites W2003834071 @default.
• W2078164585 cites W2018526785 @default.
• W2078164585 cites W2023634037 @default.
• W2078164585 cites W2032262566 @default.
• W2078164585 cites W2046080106 @default.
• W2078164585 cites W2050378500 @default.
• W2078164585 cites W2072059048 @default.
• W2078164585 cites W2079063388 @default.
• W2078164585 cites W2093106910 @default.
• W2078164585 cites W2093943904 @default.
• W2078164585 cites W2122591357 @default.
• W2078164585 cites W4232576897 @default.
• W2078164585 doi "https://doi.org/10.1016/s0006-8993(97)01284-5" @default.
• W2078164585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9519268" @default.
• W2078164585 hasPublicationYear "1998" @default.
• W2078164585 type Work @default.
• W2078164585 sameAs 2078164585 @default.
• W2078164585 citedByCount "75" @default.
• W2078164585 countsByYear W20781645852012 @default.
• W2078164585 countsByYear W20781645852013 @default.
• W2078164585 countsByYear W20781645852015 @default.
• W2078164585 countsByYear W20781645852016 @default.
• W2078164585 countsByYear W20781645852017 @default.
• W2078164585 countsByYear W20781645852019 @default.
• W2078164585 countsByYear W20781645852021 @default.
• W2078164585 crossrefType "journal-article" @default.
• W2078164585 hasAuthorship W2078164585A5028308111 @default.
• W2078164585 hasAuthorship W2078164585A5064679086 @default.
• W2078164585 hasAuthorship W2078164585A5065608007 @default.
• W2078164585 hasConcept C125667969 @default.
• W2078164585 hasConcept C126322002 @default.
• W2078164585 hasConcept C127445978 @default.
• W2078164585 hasConcept C134018914 @default.
• W2078164585 hasConcept C148762608 @default.
• W2078164585 hasConcept C169760540 @default.
• W2078164585 hasConcept C170493617 @default.
• W2078164585 hasConcept C185592680 @default.
• W2078164585 hasConcept C200170125 @default.
• W2078164585 hasConcept C2775864247 @default.
• W2078164585 hasConcept C2776219046 @default.
• W2078164585 hasConcept C2776464000 @default.
• W2078164585 hasConcept C2781161787 @default.
• W2078164585 hasConcept C29561615 @default.
• W2078164585 hasConcept C529278444 @default.
• W2078164585 hasConcept C53910766 @default.
• W2078164585 hasConcept C71924100 @default.
• W2078164585 hasConcept C86803240 @default.
• W2078164585 hasConceptScore W2078164585C125667969 @default.
• W2078164585 hasConceptScore W2078164585C126322002 @default.
• W2078164585 hasConceptScore W2078164585C127445978 @default.
• W2078164585 hasConceptScore W2078164585C134018914 @default.
• W2078164585 hasConceptScore W2078164585C148762608 @default.
• W2078164585 hasConceptScore W2078164585C169760540 @default.
• W2078164585 hasConceptScore W2078164585C170493617 @default.
• W2078164585 hasConceptScore W2078164585C185592680 @default.
• W2078164585 hasConceptScore W2078164585C200170125 @default.
• W2078164585 hasConceptScore W2078164585C2775864247 @default.
• W2078164585 hasConceptScore W2078164585C2776219046 @default.
• W2078164585 hasConceptScore W2078164585C2776464000 @default.
• W2078164585 hasConceptScore W2078164585C2781161787 @default.
• W2078164585 hasConceptScore W2078164585C29561615 @default.
• W2078164585 hasConceptScore W2078164585C529278444 @default.
• W2078164585 hasConceptScore W2078164585C53910766 @default.
• W2078164585 hasConceptScore W2078164585C71924100 @default.
• W2078164585 hasConceptScore W2078164585C86803240 @default.
• W2078164585 hasIssue "1-2" @default.
• W2078164585 hasLocation W20781645851 @default.
• W2078164585 hasLocation W20781645852 @default.
• W2078164585 hasOpenAccess W2078164585 @default.
• W2078164585 hasPrimaryLocation W20781645851 @default.
• W2078164585 hasRelatedWork W1581458838 @default.
• W2078164585 hasRelatedWork W1979782640 @default.
• W2078164585 hasRelatedWork W1987096130 @default.
• W2078164585 hasRelatedWork W2047545995 @default.
• W2078164585 hasRelatedWork W2050492453 @default.
• W2078164585 hasRelatedWork W2055572014 @default.
• W2078164585 hasRelatedWork W2081792644 @default.
• W2078164585 hasRelatedWork W2796344372 @default.
• W2078164585 hasRelatedWork W4229646661 @default.
• W2078164585 hasRelatedWork W4313236833 @default.

• next