FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078164942> ?p ?o ?g. }

• W2078164942 endingPage "99" @default.
• W2078164942 startingPage "91" @default.
• W2078164942 abstract "The effects of the transforming growth factor beta (TGF-beta) on the growth and glycosaminoglycan synthesis of rabbit growth plate-chondrocytes in culture were studied. In serum-free medium, TGF-beta caused dose-dependent inhibition of DNA synthesis by chondrocytes, measured as [3H]thymidine incorporation (ED50 = 0.1-0.3 ng/ml). The inhibitory effect was maximal at a dose of 1 ng/ml, and extended for a duration of 16-42 h. In contrast, TGF-beta potentiated the synthesis of DNA stimulated by fetal calf serum (FCS). Addition of TGF-beta (1 ng/ml) to cultures containing 10% FCS increased [3H]thymidine incorporation to 1.6-times that in cultures with 10% FCS alone. Consistent with this finding, TGF-beta potentiated DNA synthesis stimulated by the purified growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF) and fibroblast growth factor (FGF). The maximal stimulation of DNA synthesis by FGF (0.4 ng/ml) was further potentiated dose dependently by TGF-beta (ED50 = 0.1 ng/ml, maximum at 1 ng/ml). When the cultures were treated with the optimal concentrations of TGF-beta (1 ng/ml) and FGF (0.4 ng/ml), [3H]thymidine incorporation was 3-times higher than that of cultures treated with FGF alone. This TGF-beta-induced potentiation of DNA synthesis was associated with replication of chondrocytes, as shown by a marked increase in the amount of DNA during treatment of sparse cultures of the cells with the growth factors for 5 days. In contrast, TGF-beta caused dose-dependent stimulation of glycosaminoglycan synthesis in confluent cultures of growth-plate chondrocytes (ED50 = 0.3 ng/ml, maximum at 1 ng/ml). This stimulatory effect of TGF-beta was greater than that of insulin-like growth factor I (IGF-I) or PDGF. Furthermore, TGF-beta stimulated glycosaminoglycan synthesis additively with IGF-I or PDGF. Recently, it has been suggested that bone and articular cartilage are rich sources of TGF-beta, whereas epiphyseal growth cartilage is not. Thus, the present data indicate that TGF-beta may be important in bone formation by modulating growth and phenotypic expression of chondrocytes in the growth plate, possibly via a paracrine mechanism." @default.
• W2078164942 created "2016-06-24" @default.
• W2078164942 creator A5057693254 @default.
• W2078164942 creator A5060223039 @default.
• W2078164942 creator A5078475231 @default.
• W2078164942 creator A5084214689 @default.
• W2078164942 creator A5089926644 @default.
• W2078164942 date "1988-04-01" @default.
• W2078164942 modified "2023-09-23" @default.
• W2078164942 title "Effect of transforming growth factor β on cell proliferation and glycosaminoglycan synthesis by rabbit growth-plate chondrocytes in culture" @default.
• W2078164942 cites W1464779590 @default.
• W2078164942 cites W1480727199 @default.
• W2078164942 cites W1495519011 @default.
• W2078164942 cites W1496494806 @default.
• W2078164942 cites W1497792066 @default.
• W2078164942 cites W1505139655 @default.
• W2078164942 cites W1505978562 @default.
• W2078164942 cites W1509400195 @default.
• W2078164942 cites W1513452394 @default.
• W2078164942 cites W151547172 @default.
• W2078164942 cites W1524114372 @default.
• W2078164942 cites W1528585209 @default.
• W2078164942 cites W1573798987 @default.
• W2078164942 cites W1595561754 @default.
• W2078164942 cites W1980035932 @default.
• W2078164942 cites W1983909177 @default.
• W2078164942 cites W1995438729 @default.
• W2078164942 cites W2007768242 @default.
• W2078164942 cites W2014012437 @default.
• W2078164942 cites W2017603039 @default.
• W2078164942 cites W2029646746 @default.
• W2078164942 cites W2041439846 @default.
• W2078164942 cites W2052764940 @default.
• W2078164942 cites W2066978821 @default.
• W2078164942 cites W2096904163 @default.
• W2078164942 cites W2134335726 @default.
• W2078164942 cites W2144864222 @default.
• W2078164942 doi "https://doi.org/10.1016/0167-4889(88)90092-4" @default.
• W2078164942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3162385" @default.
• W2078164942 hasPublicationYear "1988" @default.
• W2078164942 type Work @default.
• W2078164942 sameAs 2078164942 @default.
• W2078164942 citedByCount "96" @default.
• W2078164942 countsByYear W20781649422012 @default.
• W2078164942 countsByYear W20781649422013 @default.
• W2078164942 countsByYear W20781649422014 @default.
• W2078164942 countsByYear W20781649422016 @default.
• W2078164942 countsByYear W20781649422017 @default.
• W2078164942 countsByYear W20781649422019 @default.
• W2078164942 countsByYear W20781649422022 @default.
• W2078164942 countsByYear W20781649422023 @default.
• W2078164942 crossrefType "journal-article" @default.
• W2078164942 hasAuthorship W2078164942A5057693254 @default.
• W2078164942 hasAuthorship W2078164942A5060223039 @default.
• W2078164942 hasAuthorship W2078164942A5078475231 @default.
• W2078164942 hasAuthorship W2078164942A5084214689 @default.
• W2078164942 hasAuthorship W2078164942A5089926644 @default.
• W2078164942 hasConcept C118131993 @default.
• W2078164942 hasConcept C126322002 @default.
• W2078164942 hasConcept C134018914 @default.
• W2078164942 hasConcept C153074725 @default.
• W2078164942 hasConcept C153911025 @default.
• W2078164942 hasConcept C170493617 @default.
• W2078164942 hasConcept C180361614 @default.
• W2078164942 hasConcept C185592680 @default.
• W2078164942 hasConcept C202751555 @default.
• W2078164942 hasConcept C2775960820 @default.
• W2078164942 hasConcept C2776362946 @default.
• W2078164942 hasConcept C2777108182 @default.
• W2078164942 hasConcept C2778229498 @default.
• W2078164942 hasConcept C2780381497 @default.
• W2078164942 hasConcept C42533223 @default.
• W2078164942 hasConcept C54355233 @default.
• W2078164942 hasConcept C552990157 @default.
• W2078164942 hasConcept C55493867 @default.
• W2078164942 hasConcept C62112901 @default.
• W2078164942 hasConcept C64241487 @default.
• W2078164942 hasConcept C71924100 @default.
• W2078164942 hasConcept C74373430 @default.
• W2078164942 hasConcept C81885089 @default.
• W2078164942 hasConcept C86803240 @default.
• W2078164942 hasConceptScore W2078164942C118131993 @default.
• W2078164942 hasConceptScore W2078164942C126322002 @default.
• W2078164942 hasConceptScore W2078164942C134018914 @default.
• W2078164942 hasConceptScore W2078164942C153074725 @default.
• W2078164942 hasConceptScore W2078164942C153911025 @default.
• W2078164942 hasConceptScore W2078164942C170493617 @default.
• W2078164942 hasConceptScore W2078164942C180361614 @default.
• W2078164942 hasConceptScore W2078164942C185592680 @default.
• W2078164942 hasConceptScore W2078164942C202751555 @default.
• W2078164942 hasConceptScore W2078164942C2775960820 @default.
• W2078164942 hasConceptScore W2078164942C2776362946 @default.
• W2078164942 hasConceptScore W2078164942C2777108182 @default.
• W2078164942 hasConceptScore W2078164942C2778229498 @default.
• W2078164942 hasConceptScore W2078164942C2780381497 @default.
• W2078164942 hasConceptScore W2078164942C42533223 @default.
• W2078164942 hasConceptScore W2078164942C54355233 @default.
• W2078164942 hasConceptScore W2078164942C552990157 @default.

• next