Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078165554> ?p ?o ?g. }
- W2078165554 endingPage "67" @default.
- W2078165554 startingPage "67" @default.
- W2078165554 abstract "Genomic and epigenetic instability in chordoma: current insights Yong Feng,1,2 Jacson K Shen,1,3 Francis J Hornicek,1,3 Zhenfeng Duan1,3 1Department of Orthopedic Surgery, Massachusetts General Hospital, Boston, MA, USA; 2Department of Orthopedic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 3Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA, USA Abstract: Chordoma is a malignant bone tumor, which currently can only be defined by histologic and immunohistochemical criteria. There are no prognostic biomarkers to predict the clinical outcome or response to treatment yet. Currently, chordoma pathogenesis is very poorly understood; however, recent large-scale genetic and epigenetic studies have identified some of the underlying mechanisms and pathways that may contribute to the disease. In this review, we summarize the most recent findings in the field of chordoma genomics and epigenomics, from comparative genomic hybridization to evaluate chromosomal alteration, large-scale deoxyribonucleic acid (DNA) sequencing to determine the gene mutation, microarray to access messenger ribonucleic acid (RNA) and microRNA gene expression, and DNA-methylation profiling. These studies may also hold valuable clinical potential in the management of chordoma. Keywords: chordoma, chromosomal alterations, sequencing, miRNA, DNA methylation" @default.
- W2078165554 created "2016-06-24" @default.
- W2078165554 creator A5034127151 @default.
- W2078165554 creator A5038077156 @default.
- W2078165554 creator A5075139931 @default.
- W2078165554 creator A5082326728 @default.
- W2078165554 date "2014-05-01" @default.
- W2078165554 modified "2023-09-26" @default.
- W2078165554 title "Genomic and epigenetic instability in chordoma: current insights" @default.
- W2078165554 cites W144423133 @default.
- W2078165554 cites W1503533733 @default.
- W2078165554 cites W1540070932 @default.
- W2078165554 cites W1563804318 @default.
- W2078165554 cites W1564861257 @default.
- W2078165554 cites W1577838670 @default.
- W2078165554 cites W1593108703 @default.
- W2078165554 cites W1613856421 @default.
- W2078165554 cites W1616948694 @default.
- W2078165554 cites W173457525 @default.
- W2078165554 cites W194458497 @default.
- W2078165554 cites W1965856472 @default.
- W2078165554 cites W1967064280 @default.
- W2078165554 cites W1967813004 @default.
- W2078165554 cites W1969174422 @default.
- W2078165554 cites W1972609538 @default.
- W2078165554 cites W1975382013 @default.
- W2078165554 cites W1975455152 @default.
- W2078165554 cites W1976944452 @default.
- W2078165554 cites W1978647823 @default.
- W2078165554 cites W1979297613 @default.
- W2078165554 cites W1981667649 @default.
- W2078165554 cites W1984301456 @default.
- W2078165554 cites W1986915398 @default.
- W2078165554 cites W1988298018 @default.
- W2078165554 cites W1990233395 @default.
- W2078165554 cites W1990521145 @default.
- W2078165554 cites W1991401267 @default.
- W2078165554 cites W1995739555 @default.
- W2078165554 cites W2000611245 @default.
- W2078165554 cites W2004078197 @default.
- W2078165554 cites W2006718746 @default.
- W2078165554 cites W2006985176 @default.
- W2078165554 cites W2007852760 @default.
- W2078165554 cites W2016380812 @default.
- W2078165554 cites W2016417531 @default.
- W2078165554 cites W2016849135 @default.
- W2078165554 cites W2017710644 @default.
- W2078165554 cites W2017725972 @default.
- W2078165554 cites W2018345916 @default.
- W2078165554 cites W2024318366 @default.
- W2078165554 cites W2025222882 @default.
- W2078165554 cites W2025596075 @default.
- W2078165554 cites W2027362881 @default.
- W2078165554 cites W2031883301 @default.
- W2078165554 cites W2038696333 @default.
- W2078165554 cites W2040257851 @default.
- W2078165554 cites W2044251801 @default.
- W2078165554 cites W2045620441 @default.
- W2078165554 cites W2046760010 @default.
- W2078165554 cites W2049029178 @default.
- W2078165554 cites W2049246409 @default.
- W2078165554 cites W2053964791 @default.
- W2078165554 cites W2060088882 @default.
- W2078165554 cites W2065105749 @default.
- W2078165554 cites W2066830586 @default.
- W2078165554 cites W2068359474 @default.
- W2078165554 cites W2072553934 @default.
- W2078165554 cites W2073995588 @default.
- W2078165554 cites W2076481272 @default.
- W2078165554 cites W2077251459 @default.
- W2078165554 cites W2080069721 @default.
- W2078165554 cites W2082594247 @default.
- W2078165554 cites W2083486480 @default.
- W2078165554 cites W2092194090 @default.
- W2078165554 cites W2092789875 @default.
- W2078165554 cites W2096473000 @default.
- W2078165554 cites W2099252068 @default.
- W2078165554 cites W2103217292 @default.
- W2078165554 cites W2111150477 @default.
- W2078165554 cites W2117009425 @default.
- W2078165554 cites W2118666976 @default.
- W2078165554 cites W2120155459 @default.
- W2078165554 cites W2129799250 @default.
- W2078165554 cites W2130346031 @default.
- W2078165554 cites W2132630169 @default.
- W2078165554 cites W2133540186 @default.
- W2078165554 cites W2135323880 @default.
- W2078165554 cites W2138582752 @default.
- W2078165554 cites W2138896702 @default.
- W2078165554 cites W2143365343 @default.
- W2078165554 cites W2153056550 @default.
- W2078165554 cites W2153089418 @default.
- W2078165554 cites W2155899435 @default.
- W2078165554 cites W2156307055 @default.
- W2078165554 cites W2161810908 @default.
- W2078165554 cites W2166253719 @default.
- W2078165554 cites W2167501668 @default.
- W2078165554 cites W2168331112 @default.