FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078165851> ?p ?o ?g. }

• W2078165851 endingPage "934" @default.
• W2078165851 startingPage "926" @default.
• W2078165851 abstract "Antibodies in sera from newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients are directed to a human islet cell protein of relative molecular mass (Mr) 64,000. Since IDDM seems to develop after a prodromal period of beta-cell autoimmunity, this study has examined whether 64,000 Mr antibodies could be detected in 14 individuals who subsequently developed IDDM and five first degree relatives who have indications of altered beta-cell function. Sera were screened by immunoprecipitation on total detergent lysates of human islets and positive sera retested on membrane protein preparations. Antibodies to the 64,000 Mr membrane protein were consistently detected in 11/14 IDDM patients, and in all 5 first degree relatives. 10 IDDM patients were already positive in the first samples, obtained 4-91 mo before the clinical onset of IDDM, whereas 1 patient progressed to a high 64,000 Mr immunoreactivity, at a time where a commencement of a decline in beta-cell function was detected. 64,000 Mr antibodies were detected before islet cell cytoplasmic antibodies (ICCA) in two patients. In the control groups of 21 healthy individuals, 36 patients with diseases of the thyroid and 5 SLE patients, the 64,000 Mr antibodies were detected in only one individual, who was a healthy sibling to an IDDM patient. These results suggest that antibodies against the Mr 64,000 human islet protein are an early marker of beta-cell autoimmunity and may be useful to predict a later development of IDDM." @default.
• W2078165851 created "2016-06-24" @default.
• W2078165851 creator A5004812350 @default.
• W2078165851 creator A5014474353 @default.
• W2078165851 creator A5015780914 @default.
• W2078165851 creator A5022508556 @default.
• W2078165851 creator A5038398583 @default.
• W2078165851 creator A5040912882 @default.
• W2078165851 creator A5043426560 @default.
• W2078165851 creator A5062071449 @default.
• W2078165851 creator A5067394833 @default.
• W2078165851 creator A5077905007 @default.
• W2078165851 date "1987-03-01" @default.
• W2078165851 modified "2023-09-27" @default.
• W2078165851 title "Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes." @default.
• W2078165851 cites W1949772429 @default.
• W2078165851 cites W1963803809 @default.
• W2078165851 cites W1987996467 @default.
• W2078165851 cites W1988606841 @default.
• W2078165851 cites W2003782659 @default.
• W2078165851 cites W2009118138 @default.
• W2078165851 cites W2018289835 @default.
• W2078165851 cites W2020125507 @default.
• W2078165851 cites W2027579971 @default.
• W2078165851 cites W2039743782 @default.
• W2078165851 cites W2044832189 @default.
• W2078165851 cites W2069260751 @default.
• W2078165851 cites W2088073185 @default.
• W2078165851 cites W2100837269 @default.
• W2078165851 cites W2103385439 @default.
• W2078165851 cites W2110931744 @default.
• W2078165851 cites W2120816431 @default.
• W2078165851 cites W2150631622 @default.
• W2078165851 cites W2164827631 @default.
• W2078165851 cites W2362248886 @default.
• W2078165851 doi "https://doi.org/10.1172/jci112903" @default.
• W2078165851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/424239" @default.
• W2078165851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3546382" @default.
• W2078165851 hasPublicationYear "1987" @default.
• W2078165851 type Work @default.
• W2078165851 sameAs 2078165851 @default.
• W2078165851 citedByCount "300" @default.
• W2078165851 countsByYear W20781658512012 @default.
• W2078165851 countsByYear W20781658512013 @default.
• W2078165851 countsByYear W20781658512014 @default.
• W2078165851 countsByYear W20781658512015 @default.
• W2078165851 countsByYear W20781658512016 @default.
• W2078165851 countsByYear W20781658512017 @default.
• W2078165851 countsByYear W20781658512018 @default.
• W2078165851 countsByYear W20781658512019 @default.
• W2078165851 countsByYear W20781658512020 @default.
• W2078165851 crossrefType "journal-article" @default.
• W2078165851 hasAuthorship W2078165851A5004812350 @default.
• W2078165851 hasAuthorship W2078165851A5014474353 @default.
• W2078165851 hasAuthorship W2078165851A5015780914 @default.
• W2078165851 hasAuthorship W2078165851A5022508556 @default.
• W2078165851 hasAuthorship W2078165851A5038398583 @default.
• W2078165851 hasAuthorship W2078165851A5040912882 @default.
• W2078165851 hasAuthorship W2078165851A5043426560 @default.
• W2078165851 hasAuthorship W2078165851A5062071449 @default.
• W2078165851 hasAuthorship W2078165851A5067394833 @default.
• W2078165851 hasAuthorship W2078165851A5077905007 @default.
• W2078165851 hasBestOaLocation W20781658511 @default.
• W2078165851 hasConcept C126322002 @default.
• W2078165851 hasConcept C134018914 @default.
• W2078165851 hasConcept C159654299 @default.
• W2078165851 hasConcept C163764329 @default.
• W2078165851 hasConcept C165220095 @default.
• W2078165851 hasConcept C203014093 @default.
• W2078165851 hasConcept C2776828364 @default.
• W2078165851 hasConcept C2780130043 @default.
• W2078165851 hasConcept C2781232474 @default.
• W2078165851 hasConcept C555293320 @default.
• W2078165851 hasConcept C71924100 @default.
• W2078165851 hasConceptScore W2078165851C126322002 @default.
• W2078165851 hasConceptScore W2078165851C134018914 @default.
• W2078165851 hasConceptScore W2078165851C159654299 @default.
• W2078165851 hasConceptScore W2078165851C163764329 @default.
• W2078165851 hasConceptScore W2078165851C165220095 @default.
• W2078165851 hasConceptScore W2078165851C203014093 @default.
• W2078165851 hasConceptScore W2078165851C2776828364 @default.
• W2078165851 hasConceptScore W2078165851C2780130043 @default.
• W2078165851 hasConceptScore W2078165851C2781232474 @default.
• W2078165851 hasConceptScore W2078165851C555293320 @default.
• W2078165851 hasConceptScore W2078165851C71924100 @default.
• W2078165851 hasIssue "3" @default.
• W2078165851 hasLocation W20781658511 @default.
• W2078165851 hasLocation W20781658512 @default.
• W2078165851 hasLocation W20781658513 @default.
• W2078165851 hasLocation W20781658514 @default.
• W2078165851 hasLocation W20781658515 @default.
• W2078165851 hasOpenAccess W2078165851 @default.
• W2078165851 hasPrimaryLocation W20781658511 @default.
• W2078165851 hasRelatedWork W2035871243 @default.
• W2078165851 hasRelatedWork W2039773086 @default.
• W2078165851 hasRelatedWork W2043428857 @default.
• W2078165851 hasRelatedWork W2069537429 @default.
• W2078165851 hasRelatedWork W2098197630 @default.

• next