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- W2078166953 endingPage "849" @default.
- W2078166953 startingPage "838" @default.
- W2078166953 abstract "Many studies are accumulating that report the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. While there has been a major focus on the antioxidant properties, there is an emerging view that flavonoids, and their in vivo metabolites, do not act as conventional hydrogen-donating antioxidants but may exert modulatory actions in cells through actions at protein kinase and lipid kinase signalling pathways. Flavonoids, and more recently their metabolites, have been reported to act at phosphoinositide 3-kinase (PI 3-kinase), Akt/protein kinase B (Akt/PKB), tyrosine kinases, protein kinase C (PKC), and mitogen activated protein kinase (MAP kinase) signalling cascades. Inhibitory or stimulatory actions at these pathways are likely to affect cellular function profoundly by altering the phosphorylation state of target molecules and by modulating gene expression. A clear understanding of the mechanisms of action of flavonoids, either as antioxidants or modulators of cell signalling, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anticancer agents, cardioprotectants, and inhibitors of neurodegeneration" @default.
- W2078166953 created "2016-06-24" @default.
- W2078166953 creator A5009786597 @default.
- W2078166953 creator A5046912319 @default.
- W2078166953 creator A5081513258 @default.
- W2078166953 date "2004-04-01" @default.
- W2078166953 modified "2023-10-11" @default.
- W2078166953 title "Flavonoids: antioxidants or signalling molecules?" @default.
- W2078166953 cites W1482444548 @default.
- W2078166953 cites W1491979926 @default.
- W2078166953 cites W1492349549 @default.
- W2078166953 cites W1504990433 @default.
- W2078166953 cites W1529396499 @default.
- W2078166953 cites W1540436551 @default.
- W2078166953 cites W1541035567 @default.
- W2078166953 cites W1542677221 @default.
- W2078166953 cites W1550903142 @default.
- W2078166953 cites W1564012501 @default.
- W2078166953 cites W1618299283 @default.
- W2078166953 cites W1791888878 @default.
- W2078166953 cites W1967996072 @default.
- W2078166953 cites W1968887262 @default.
- W2078166953 cites W1971305021 @default.
- W2078166953 cites W1971442892 @default.
- W2078166953 cites W1973668297 @default.
- W2078166953 cites W1973907050 @default.
- W2078166953 cites W1975672084 @default.
- W2078166953 cites W1976385326 @default.
- W2078166953 cites W1976441097 @default.
- W2078166953 cites W1977633602 @default.
- W2078166953 cites W1980790707 @default.
- W2078166953 cites W1981969869 @default.
- W2078166953 cites W1985554733 @default.
- W2078166953 cites W1986463236 @default.
- W2078166953 cites W1987280193 @default.
- W2078166953 cites W1990264946 @default.
- W2078166953 cites W1992377755 @default.
- W2078166953 cites W1992925554 @default.
- W2078166953 cites W1997539317 @default.
- W2078166953 cites W1998061626 @default.
- W2078166953 cites W1998839686 @default.
- W2078166953 cites W1999605572 @default.
- W2078166953 cites W2000413909 @default.
- W2078166953 cites W2000683639 @default.
- W2078166953 cites W2001276434 @default.
- W2078166953 cites W2004126223 @default.
- W2078166953 cites W2007468478 @default.
- W2078166953 cites W2007982299 @default.
- W2078166953 cites W2008490492 @default.
- W2078166953 cites W2008750119 @default.
- W2078166953 cites W2008955668 @default.
- W2078166953 cites W2015928700 @default.
- W2078166953 cites W2022766782 @default.
- W2078166953 cites W2024656201 @default.
- W2078166953 cites W2026824792 @default.
- W2078166953 cites W2028244585 @default.
- W2078166953 cites W2028407281 @default.
- W2078166953 cites W2030573603 @default.
- W2078166953 cites W2031785137 @default.
- W2078166953 cites W2032494683 @default.
- W2078166953 cites W2033767311 @default.
- W2078166953 cites W2034865244 @default.
- W2078166953 cites W2036126222 @default.
- W2078166953 cites W2038700930 @default.
- W2078166953 cites W2041421828 @default.
- W2078166953 cites W2042592567 @default.
- W2078166953 cites W2044031210 @default.
- W2078166953 cites W2045067023 @default.
- W2078166953 cites W2047503046 @default.
- W2078166953 cites W2047571097 @default.
- W2078166953 cites W2050666671 @default.
- W2078166953 cites W2054632770 @default.
- W2078166953 cites W2058039225 @default.
- W2078166953 cites W2059201682 @default.
- W2078166953 cites W2060479161 @default.
- W2078166953 cites W2061482527 @default.
- W2078166953 cites W2063429313 @default.
- W2078166953 cites W2064194276 @default.
- W2078166953 cites W2065568526 @default.
- W2078166953 cites W2067637864 @default.
- W2078166953 cites W2068569457 @default.
- W2078166953 cites W2068954050 @default.
- W2078166953 cites W2069033237 @default.
- W2078166953 cites W2072756792 @default.
- W2078166953 cites W2075990443 @default.
- W2078166953 cites W2076485183 @default.
- W2078166953 cites W2076728391 @default.
- W2078166953 cites W2077233143 @default.
- W2078166953 cites W2079153899 @default.
- W2078166953 cites W2086255122 @default.
- W2078166953 cites W2086959952 @default.
- W2078166953 cites W2090007731 @default.
- W2078166953 cites W2090393867 @default.
- W2078166953 cites W2093628776 @default.
- W2078166953 cites W2094155854 @default.
- W2078166953 cites W2097767970 @default.
- W2078166953 cites W2099000660 @default.
- W2078166953 cites W2099821002 @default.