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• W2078169024 abstract "In this study we report novel findings regarding the evolutionary relationship between gene duplication and alternative splicing, two processes that increase proteomic diversity. By studying teleost fish, we find that gene duplication followed by exon structure divergence between paralogs, but not gene duplication alone, leads to a significant reduction in alternative splicing, as measured by both the proportion of genes that undergo alternative splicing as well as mean number of transcripts per gene. Additionally, we show that this effect is independent of gene family size and gene function. Furthermore, we provide evidence that the reduction in alternative splicing may be due to the partitioning of ancestral splice forms among the duplicate genes - a form of subfunctionalization. Taken together these results indicate that exon structure evolution subsequent to gene duplication may be a common substitute for alternative splicing." @default.
• W2078169024 created "2016-06-24" @default.
• W2078169024 creator A5021583457 @default.
• W2078169024 creator A5024425117 @default.
• W2078169024 creator A5024460142 @default.
• W2078169024 date "2014-08-01" @default.
• W2078169024 modified "2023-09-27" @default.
• W2078169024 title "Gene duplication followed by exon structure divergence substitutes for alternative splicing in zebrafish" @default.
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• W2078169024 doi "https://doi.org/10.1016/j.gene.2014.05.068" @default.
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