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- W2078169039 abstract "Background: Caffeine (CAF) is the most consumed psychostimulant worldwide, and it is frequently associated with the consumption of several other drugs, including alcohol. This study was designed to evaluate the pattern of ethanol consumption and the propensity to show an alcohol deprivation effect (ADE) in rats exposed to voluntary intake of caffeinated alcoholic solutions. Methods: Male Wistar rats were given unlimited access to a two-bottle choice procedure. Rats were divided into two groups: control and CAF and submitted to a free-choice water versus 0.1% (w/v) saccharin (SAC) solution prepared with or without 1 g/L of CAF. Subsequently, control and CAF groups were subdivided into four groups: EtOH, EtOH+SAC, EtOH+CAF, and EtOH+SAC+CAF (n=7–8), and allowed to drink alcoholic solutions of increasing concentrations (3%, 6%, and 10%) for 50 days. ADE was assessed after an abstinence period of 7 days. Results: Both control and CAF groups preferred to drink and drank more SAC solution than regular tap water..." @default.
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- W2078169039 date "2012-06-01" @default.
- W2078169039 modified "2023-09-27" @default.
- W2078169039 title "Prolonged Exposure to Caffeinated Alcoholic Solutions Prevents the Alcohol Deprivation Effect in Rats" @default.
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- W2078169039 doi "https://doi.org/10.1089/jcr.2012.0013" @default.
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