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• W2078169688 startingPage "213" @default.
• W2078169688 abstract "Peptides deriving from the proenkephalin B precursor were studied in the Ungerstedt rotational model after their unilateral injection into the substantia nigra. Dynorphin (DYN)-(1-17), DYN-(1-13) and DYN-(1-8) in 0.1-10 micrograms doses induced marked contralateral rotation. This effect was enhanced by subsequent systemic administration of D-amphetamine and blocked by previous treatment with naloxone. alpha-Neoendorphin produced similar effects although there was no evidence for dose-dependency. DYN-(6-17) which lacks opioid activity also produced contralateral rotation, which, however, was not naloxone reversible and D-amphetamine given subsequently did not induce asymmetric activation. Methionine enkephalin and leucine enkephalin, deriving from the proenkephalin A precursor were tested for comparison. Only the former produced weak contralateral rotation. GABA injected at the same site as DYN-(1-17) also induced contralateral rotation which was mimicked by nanogram doses of the gabaergic agonist muscimol. These findings suggest an interaction between peptides from the proenkephalin B precursor and nigro-striatal dopamine neurons as well as gabaergic striato-nigral efferents and/or interneurons." @default.
• W2078169688 created "2016-06-24" @default.
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• W2078169688 date "1984-07-01" @default.
• W2078169688 modified "2023-09-26" @default.
• W2078169688 title "Effect of intranigral injections of dynorphin, dynorphin fragments and α-neoendorphin on rotational behaviour in the rat" @default.
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• W2078169688 doi "https://doi.org/10.1016/0014-2999(84)90253-x" @default.
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