Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078170456> ?p ?o ?g. }
- W2078170456 endingPage "2346" @default.
- W2078170456 startingPage "2335" @default.
- W2078170456 abstract "Previous efforts to derive lung progenitor cells from human embryonic stem (hES) cells using embryoid body formation or stromal feeder cocultures had been limited by low efficiencies. Here, we report a step-wise differentiation method to drive both hES and induced pluripotent stem (iPS) cells toward the lung lineage. Our data demonstrated a 30% efficiency in generating lung epithelial cells (LECs) that expresses various distal lung markers. Further enrichment of lung progenitor cells using a stem cell marker, CD166 before transplantation into bleomycin-injured NOD/SCID mice resulted in enhanced survivability of mice and improved lung pulmonary functions. Immunohistochemistry of lung sections from surviving mice further confirmed the specific engraftment of transplanted cells in the damaged lung. These cells were shown to express surfactant protein C, a specific marker for distal lung progenitor in the alveoli. Our study has therefore demonstrated the proof-of-concept of using iPS cells for the repair of acute lung injury, demonstrating the potential usefulness of using patient's own iPS cells to prevent immune rejection which arise from allogenic transplantation." @default.
- W2078170456 created "2016-06-24" @default.
- W2078170456 creator A5000006966 @default.
- W2078170456 creator A5000050947 @default.
- W2078170456 creator A5008473414 @default.
- W2078170456 creator A5014307352 @default.
- W2078170456 creator A5027146937 @default.
- W2078170456 creator A5032791503 @default.
- W2078170456 creator A5035452273 @default.
- W2078170456 creator A5042322286 @default.
- W2078170456 creator A5045082338 @default.
- W2078170456 creator A5055212310 @default.
- W2078170456 creator A5055553069 @default.
- W2078170456 creator A5059923178 @default.
- W2078170456 creator A5063869673 @default.
- W2078170456 creator A5066748955 @default.
- W2078170456 creator A5070436450 @default.
- W2078170456 creator A5071127344 @default.
- W2078170456 creator A5079793234 @default.
- W2078170456 creator A5085404684 @default.
- W2078170456 creator A5088338470 @default.
- W2078170456 creator A5089082457 @default.
- W2078170456 date "2012-12-01" @default.
- W2078170456 modified "2023-10-07" @default.
- W2078170456 title "CD166pos Subpopulation From Differentiated Human ES and iPS Cells Support Repair of Acute Lung Injury" @default.
- W2078170456 cites W1599568627 @default.
- W2078170456 cites W1965241231 @default.
- W2078170456 cites W1987774343 @default.
- W2078170456 cites W1990975603 @default.
- W2078170456 cites W1991707124 @default.
- W2078170456 cites W1992358636 @default.
- W2078170456 cites W2005356516 @default.
- W2078170456 cites W2012471677 @default.
- W2078170456 cites W2015243651 @default.
- W2078170456 cites W2016823790 @default.
- W2078170456 cites W2021371565 @default.
- W2078170456 cites W2023607197 @default.
- W2078170456 cites W2027267818 @default.
- W2078170456 cites W2038404321 @default.
- W2078170456 cites W2039813966 @default.
- W2078170456 cites W2040111843 @default.
- W2078170456 cites W2041180426 @default.
- W2078170456 cites W2041817852 @default.
- W2078170456 cites W2063779394 @default.
- W2078170456 cites W2067114333 @default.
- W2078170456 cites W2068311284 @default.
- W2078170456 cites W2070006053 @default.
- W2078170456 cites W2071142855 @default.
- W2078170456 cites W2072398160 @default.
- W2078170456 cites W2078310910 @default.
- W2078170456 cites W2078323858 @default.
- W2078170456 cites W2081406906 @default.
- W2078170456 cites W2084276316 @default.
- W2078170456 cites W2084901240 @default.
- W2078170456 cites W2095301170 @default.
- W2078170456 cites W2118933841 @default.
- W2078170456 cites W2124396531 @default.
- W2078170456 cites W2126091764 @default.
- W2078170456 cites W2138977668 @default.
- W2078170456 cites W2139373056 @default.
- W2078170456 cites W2139522359 @default.
- W2078170456 cites W2147156629 @default.
- W2078170456 cites W2150103989 @default.
- W2078170456 cites W2150526060 @default.
- W2078170456 cites W2154713489 @default.
- W2078170456 cites W2157341735 @default.
- W2078170456 cites W2161164081 @default.
- W2078170456 cites W2162089683 @default.
- W2078170456 cites W2165871414 @default.
- W2078170456 cites W2166628699 @default.
- W2078170456 cites W2180585852 @default.
- W2078170456 doi "https://doi.org/10.1038/mt.2012.182" @default.
- W2078170456 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3519990" @default.
- W2078170456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22968480" @default.
- W2078170456 hasPublicationYear "2012" @default.
- W2078170456 type Work @default.
- W2078170456 sameAs 2078170456 @default.
- W2078170456 citedByCount "24" @default.
- W2078170456 countsByYear W20781704562013 @default.
- W2078170456 countsByYear W20781704562014 @default.
- W2078170456 countsByYear W20781704562015 @default.
- W2078170456 countsByYear W20781704562016 @default.
- W2078170456 countsByYear W20781704562017 @default.
- W2078170456 countsByYear W20781704562018 @default.
- W2078170456 countsByYear W20781704562020 @default.
- W2078170456 countsByYear W20781704562021 @default.
- W2078170456 countsByYear W20781704562022 @default.
- W2078170456 countsByYear W20781704562023 @default.
- W2078170456 crossrefType "journal-article" @default.
- W2078170456 hasAuthorship W2078170456A5000006966 @default.
- W2078170456 hasAuthorship W2078170456A5000050947 @default.
- W2078170456 hasAuthorship W2078170456A5008473414 @default.
- W2078170456 hasAuthorship W2078170456A5014307352 @default.
- W2078170456 hasAuthorship W2078170456A5027146937 @default.
- W2078170456 hasAuthorship W2078170456A5032791503 @default.
- W2078170456 hasAuthorship W2078170456A5035452273 @default.
- W2078170456 hasAuthorship W2078170456A5042322286 @default.
- W2078170456 hasAuthorship W2078170456A5045082338 @default.