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- W2078172004 abstract "The ingestion and killing of Staphylococcus aureus by peripheral blood leucocytes from 130 patients with infectious and non-infectious diseases have been determined, using an improved technique for the evaluation of neutrophil granulocyte function in vitro. A reversible defect in intraleucocytic killing could be demonstrated in granulocytes from patients with severe bacterial infections whereas granulocytes from patients with viral infections and non-infectious diseases showed only minor deviations from normal function by this technique. This defect could furthermore be attributed to malfunction of myeloperoxidase-mediated bactericidal systems and was found to be positively related to the degree of “shift to the left” of circulating myeloid cells. A similar defect could also be demonstrated in some patients with non-infectious granulocytosis. It is suggested that this defect may be caused by malfunction of a subpopulation of immature myeloid cells and/or by altered granulocyte function caused by in vivo activation of the cells due to immune reactions." @default.
- W2078172004 created "2016-06-24" @default.
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- W2078172004 date "2009-08-15" @default.
- W2078172004 modified "2023-09-25" @default.
- W2078172004 title "ACQUIRED DEFECT IN THE BACTERICIDAL FUNCTION OF NEUTROPHIL GRANULOCYTES DURING BACTERIAL INFECTIONS" @default.
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- W2078172004 doi "https://doi.org/10.1111/j.1699-0463.1974.tb02348.x" @default.
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