Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078172920> ?p ?o ?g. }
- W2078172920 endingPage "1050" @default.
- W2078172920 startingPage "1038" @default.
- W2078172920 abstract "Neuronal thread proteins (NTPs) comprise a family of molecules expressed in brain and primitive neuroectodermal tumor cell lines. In Alzheimer's disease (AD), increased CNS levels of the 21 kD NTP species are correlated with dementia. The present study characterizes the nature and distribution of NTP expression using recently generated brain-derived polyclonal and monoclonal antibodies (MoAbs) to recombinant AD7c-NTP protein. In AD, high levels of NTP immunoreactivity were detected in neuronal perikarya, neuropil fibers, and white matter fibers (axons). In addition, 4 of the 23 AD7c-NTP MoAbs labeled degenerating neurons (with or without neurofibrillary tangles), axonal spheroids, dystrophic neurites, or irregular, wavy threadlike neuropil fibers in AD. Increased neuronal AD7c-NTP immunoreactivity in AD colocalized with perikarya] accumulations of tau-1, phosphorylated neurofilament, and the ganglioside, A2B5. In addition, AD7c-NTP immunoreactivity was detected in early neuritic plaques along with β-amyloid-containing fibrils, but not in mature plaques, nor was it colocalized in βA4-immunoreactive fibrils. This study demonstrates the profiles of NTP overexpression in relation to paired helical filament-associated neurodegenerative lesions in AD." @default.
- W2078172920 created "2016-06-24" @default.
- W2078172920 creator A5014095062 @default.
- W2078172920 creator A5028769708 @default.
- W2078172920 creator A5031942214 @default.
- W2078172920 creator A5043258226 @default.
- W2078172920 date "1996-10-01" @default.
- W2078172920 modified "2023-09-27" @default.
- W2078172920 title "Profiles of Neuronal Thread Protein Expression in Alzheimer's Disease" @default.
- W2078172920 doi "https://doi.org/10.1097/00005072-199655100-00004" @default.
- W2078172920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8858001" @default.
- W2078172920 hasPublicationYear "1996" @default.
- W2078172920 type Work @default.
- W2078172920 sameAs 2078172920 @default.
- W2078172920 citedByCount "42" @default.
- W2078172920 countsByYear W20781729202012 @default.
- W2078172920 countsByYear W20781729202013 @default.
- W2078172920 countsByYear W20781729202014 @default.
- W2078172920 countsByYear W20781729202015 @default.
- W2078172920 countsByYear W20781729202016 @default.
- W2078172920 countsByYear W20781729202017 @default.
- W2078172920 countsByYear W20781729202018 @default.
- W2078172920 countsByYear W20781729202019 @default.
- W2078172920 countsByYear W20781729202020 @default.
- W2078172920 countsByYear W20781729202021 @default.
- W2078172920 countsByYear W20781729202022 @default.
- W2078172920 countsByYear W20781729202023 @default.
- W2078172920 crossrefType "journal-article" @default.
- W2078172920 hasAuthorship W2078172920A5014095062 @default.
- W2078172920 hasAuthorship W2078172920A5028769708 @default.
- W2078172920 hasAuthorship W2078172920A5031942214 @default.
- W2078172920 hasAuthorship W2078172920A5043258226 @default.
- W2078172920 hasBestOaLocation W20781729201 @default.
- W2078172920 hasConcept C113246987 @default.
- W2078172920 hasConcept C142724271 @default.
- W2078172920 hasConcept C153911025 @default.
- W2078172920 hasConcept C157207234 @default.
- W2078172920 hasConcept C159654299 @default.
- W2078172920 hasConcept C169760540 @default.
- W2078172920 hasConcept C202751555 @default.
- W2078172920 hasConcept C203014093 @default.
- W2078172920 hasConcept C204232928 @default.
- W2078172920 hasConcept C27523624 @default.
- W2078172920 hasConcept C2777331542 @default.
- W2078172920 hasConcept C2777427615 @default.
- W2078172920 hasConcept C2777831001 @default.
- W2078172920 hasConcept C2779134260 @default.
- W2078172920 hasConcept C2779281540 @default.
- W2078172920 hasConcept C2779721402 @default.
- W2078172920 hasConcept C502032728 @default.
- W2078172920 hasConcept C529278444 @default.
- W2078172920 hasConcept C542903549 @default.
- W2078172920 hasConcept C55493867 @default.
- W2078172920 hasConcept C68026918 @default.
- W2078172920 hasConcept C71924100 @default.
- W2078172920 hasConcept C86803240 @default.
- W2078172920 hasConcept C95444343 @default.
- W2078172920 hasConceptScore W2078172920C113246987 @default.
- W2078172920 hasConceptScore W2078172920C142724271 @default.
- W2078172920 hasConceptScore W2078172920C153911025 @default.
- W2078172920 hasConceptScore W2078172920C157207234 @default.
- W2078172920 hasConceptScore W2078172920C159654299 @default.
- W2078172920 hasConceptScore W2078172920C169760540 @default.
- W2078172920 hasConceptScore W2078172920C202751555 @default.
- W2078172920 hasConceptScore W2078172920C203014093 @default.
- W2078172920 hasConceptScore W2078172920C204232928 @default.
- W2078172920 hasConceptScore W2078172920C27523624 @default.
- W2078172920 hasConceptScore W2078172920C2777331542 @default.
- W2078172920 hasConceptScore W2078172920C2777427615 @default.
- W2078172920 hasConceptScore W2078172920C2777831001 @default.
- W2078172920 hasConceptScore W2078172920C2779134260 @default.
- W2078172920 hasConceptScore W2078172920C2779281540 @default.
- W2078172920 hasConceptScore W2078172920C2779721402 @default.
- W2078172920 hasConceptScore W2078172920C502032728 @default.
- W2078172920 hasConceptScore W2078172920C529278444 @default.
- W2078172920 hasConceptScore W2078172920C542903549 @default.
- W2078172920 hasConceptScore W2078172920C55493867 @default.
- W2078172920 hasConceptScore W2078172920C68026918 @default.
- W2078172920 hasConceptScore W2078172920C71924100 @default.
- W2078172920 hasConceptScore W2078172920C86803240 @default.
- W2078172920 hasConceptScore W2078172920C95444343 @default.
- W2078172920 hasIssue "10" @default.
- W2078172920 hasLocation W20781729201 @default.
- W2078172920 hasLocation W20781729202 @default.
- W2078172920 hasOpenAccess W2078172920 @default.
- W2078172920 hasPrimaryLocation W20781729201 @default.
- W2078172920 hasRelatedWork W1250647964 @default.
- W2078172920 hasRelatedWork W1457612827 @default.
- W2078172920 hasRelatedWork W1992671570 @default.
- W2078172920 hasRelatedWork W2028590450 @default.
- W2078172920 hasRelatedWork W2076272666 @default.
- W2078172920 hasRelatedWork W2078172920 @default.
- W2078172920 hasRelatedWork W2400196309 @default.
- W2078172920 hasRelatedWork W2470304679 @default.
- W2078172920 hasRelatedWork W4256337081 @default.
- W2078172920 hasRelatedWork W612884020 @default.
- W2078172920 hasVolume "55" @default.
- W2078172920 isParatext "false" @default.