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- W2078173351 abstract "Mild hyperhomocystinemia has been suggested as an indicator of an increased risk of cardiovascular disease.To examine whether serum homocysteine concentration is a predictor of coronary heart disease (CHD) events.A case-control study, nested in a population-based cohort study was used. During a follow-up of 13 years, 166 major coronary events (death from CHD or nonfatal myocardial infarction) occurred in men with evidence of heart disease at baseline and 272 events in men without a history of heart disease. Two controls per case were selected by individual matching.Among men with known heart disease at baseline, the relative risk (95% confidence interval) of CHD events adjusted for age, smoking, hypertension, diabetes mellitus, serum cholesterol level, body mass index, and alcohol consumption was 2.23 (95% confidence interval, 1.03-4.85) in the highest serum homocysteine quintile compared with the lowest quintile. Among the men free of heart disease at baseline, the corresponding relative risk was 0.90 (95% confidence interval, 0.51-1.60).This prospective study does not support the hypothesis that a high concentration of serum homocysteine is a risk factor for coronary events in a population free of heart disease. However, it does suggest that mild hyperhomocystinemia predicts secondary coronary events in men with heart disease, possibly as a consequence of atherosclerotic changes." @default.
- W2078173351 created "2016-06-24" @default.
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- W2078173351 date "2001-07-09" @default.
- W2078173351 modified "2023-10-16" @default.
- W2078173351 title "Hyperhomocystinemia" @default.
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- W2078173351 doi "https://doi.org/10.1001/archinte.161.13.1589" @default.
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