Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078173638> ?p ?o ?g. }
- W2078173638 endingPage "356" @default.
- W2078173638 startingPage "343" @default.
- W2078173638 abstract "IL12B is required for resistance to Mycobacterium tuberculosis (Mtb) infection, promoting the initiation and maintenance of Mtb-specific effector responses. While this makes the IL12-pathway an attractive target for experimental tuberculosis (TB) therapies, data regarding what lineages express IL12B after infection is established are limited. This is not obvious in the lung, an organ in which both hematopoietic and non-hematopoietic lineages produce IL12p40 upon pathogen encounter. Here, we use radiation bone marrow chimeras and Yet40 reporter mice to determine what lineages produce IL12p40 during experimental TB. We observed that hematopoietic IL12p40-production was sufficient to control Mtb, with no contribution by non-hematopoietic lineages. Furthermore, rather than being produced by a single subset, IL12p40 was produced by cells that were heterogenous in their size, granularity, autofluorescence and expression of CD11c, CD11b and CD8α. While depending on the timepoint and tissue examined, the surface phenotype of IL12p40-producers most closely resembled macrophages based on previous surveys of lung myeloid lineages. Importantly, depletion of CD11c(hi) cells during infection had no affect on lung IL12p40-concentrations. Collectively, our data demonstrate that IL12p40 production is sustained by a heterogenous population of myeloid lineages during experimental TB, and that redundant mechanisms of IL12p40-production exist when CD11c(hi) lineages are absent." @default.
- W2078173638 created "2016-06-24" @default.
- W2078173638 creator A5003452184 @default.
- W2078173638 creator A5041860029 @default.
- W2078173638 creator A5062279144 @default.
- W2078173638 date "2013-05-01" @default.
- W2078173638 modified "2023-09-23" @default.
- W2078173638 title "IL12B expression is sustained by a heterogenous population of myeloid lineages during tuberculosis" @default.
- W2078173638 cites W1479876200 @default.
- W2078173638 cites W1506273507 @default.
- W2078173638 cites W1509377507 @default.
- W2078173638 cites W1509960657 @default.
- W2078173638 cites W1514540900 @default.
- W2078173638 cites W1567198647 @default.
- W2078173638 cites W1596274918 @default.
- W2078173638 cites W1642525842 @default.
- W2078173638 cites W1659095239 @default.
- W2078173638 cites W1765079284 @default.
- W2078173638 cites W1838853754 @default.
- W2078173638 cites W1847326477 @default.
- W2078173638 cites W1965206234 @default.
- W2078173638 cites W1965453859 @default.
- W2078173638 cites W1968289697 @default.
- W2078173638 cites W1968388155 @default.
- W2078173638 cites W1973985508 @default.
- W2078173638 cites W1976899534 @default.
- W2078173638 cites W1978364383 @default.
- W2078173638 cites W1979601875 @default.
- W2078173638 cites W1979876156 @default.
- W2078173638 cites W1981038069 @default.
- W2078173638 cites W1982794340 @default.
- W2078173638 cites W1985779248 @default.
- W2078173638 cites W2001802908 @default.
- W2078173638 cites W2002988406 @default.
- W2078173638 cites W2006741811 @default.
- W2078173638 cites W2012178961 @default.
- W2078173638 cites W2023061016 @default.
- W2078173638 cites W2024868455 @default.
- W2078173638 cites W2027562913 @default.
- W2078173638 cites W2029898329 @default.
- W2078173638 cites W2035607660 @default.
- W2078173638 cites W2038376094 @default.
- W2078173638 cites W2044325609 @default.
- W2078173638 cites W2044936732 @default.
- W2078173638 cites W2046205086 @default.
- W2078173638 cites W2046447606 @default.
- W2078173638 cites W2047385405 @default.
- W2078173638 cites W2048500103 @default.
- W2078173638 cites W2051960468 @default.
- W2078173638 cites W2054023194 @default.
- W2078173638 cites W2056521763 @default.
- W2078173638 cites W2057877742 @default.
- W2078173638 cites W2059428439 @default.
- W2078173638 cites W2063053561 @default.
- W2078173638 cites W2065100101 @default.
- W2078173638 cites W2072383862 @default.
- W2078173638 cites W2078676553 @default.
- W2078173638 cites W2078710631 @default.
- W2078173638 cites W2080854864 @default.
- W2078173638 cites W2080911945 @default.
- W2078173638 cites W2087905758 @default.
- W2078173638 cites W2096943421 @default.
- W2078173638 cites W2098376804 @default.
- W2078173638 cites W2098907119 @default.
- W2078173638 cites W2100219680 @default.
- W2078173638 cites W2100531445 @default.
- W2078173638 cites W2100872199 @default.
- W2078173638 cites W2100990607 @default.
- W2078173638 cites W2101411328 @default.
- W2078173638 cites W2102156468 @default.
- W2078173638 cites W2102578857 @default.
- W2078173638 cites W2108994196 @default.
- W2078173638 cites W2111570053 @default.
- W2078173638 cites W2111954628 @default.
- W2078173638 cites W2112628232 @default.
- W2078173638 cites W2115440312 @default.
- W2078173638 cites W2116355544 @default.
- W2078173638 cites W2117964443 @default.
- W2078173638 cites W2118842534 @default.
- W2078173638 cites W2119803995 @default.
- W2078173638 cites W2120081597 @default.
- W2078173638 cites W2121499583 @default.
- W2078173638 cites W2123888778 @default.
- W2078173638 cites W2124018243 @default.
- W2078173638 cites W2125576737 @default.
- W2078173638 cites W2126593444 @default.
- W2078173638 cites W2129442719 @default.
- W2078173638 cites W2130968927 @default.
- W2078173638 cites W2132304218 @default.
- W2078173638 cites W2133071747 @default.
- W2078173638 cites W2133922377 @default.
- W2078173638 cites W2135254713 @default.
- W2078173638 cites W2135437388 @default.
- W2078173638 cites W2136188258 @default.
- W2078173638 cites W2137986448 @default.
- W2078173638 cites W2143500103 @default.
- W2078173638 cites W2145078103 @default.
- W2078173638 cites W2147122611 @default.